Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
Lineage differentiation and commitment is driven by transcription regulators and chromatin changes. Here the authors report daily profiling of chromatin accessibility and transcriptome changes during human erythropoiesis, relating these changes to lineage potential between erythropoiesis and megakar...
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2021
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oai:doaj.org-article:6afaac0110ec4c4498a1abfc81a3695b2021-11-28T12:32:23ZDiscrete regulatory modules instruct hematopoietic lineage commitment and differentiation10.1038/s41467-021-27159-x2041-1723https://doaj.org/article/6afaac0110ec4c4498a1abfc81a3695b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27159-xhttps://doaj.org/toc/2041-1723Lineage differentiation and commitment is driven by transcription regulators and chromatin changes. Here the authors report daily profiling of chromatin accessibility and transcriptome changes during human erythropoiesis, relating these changes to lineage potential between erythropoiesis and megakaryopoieis.Grigorios GeorgolopoulosNikoletta PsathaMineo IwataAndrew NishidaTannishtha SomMinas YiangouJohn A. StamatoyannopoulosJeff VierstraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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Science Q Grigorios Georgolopoulos Nikoletta Psatha Mineo Iwata Andrew Nishida Tannishtha Som Minas Yiangou John A. Stamatoyannopoulos Jeff Vierstra Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
description |
Lineage differentiation and commitment is driven by transcription regulators and chromatin changes. Here the authors report daily profiling of chromatin accessibility and transcriptome changes during human erythropoiesis, relating these changes to lineage potential between erythropoiesis and megakaryopoieis. |
format |
article |
author |
Grigorios Georgolopoulos Nikoletta Psatha Mineo Iwata Andrew Nishida Tannishtha Som Minas Yiangou John A. Stamatoyannopoulos Jeff Vierstra |
author_facet |
Grigorios Georgolopoulos Nikoletta Psatha Mineo Iwata Andrew Nishida Tannishtha Som Minas Yiangou John A. Stamatoyannopoulos Jeff Vierstra |
author_sort |
Grigorios Georgolopoulos |
title |
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
title_short |
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
title_full |
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
title_fullStr |
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
title_full_unstemmed |
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
title_sort |
discrete regulatory modules instruct hematopoietic lineage commitment and differentiation |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/6afaac0110ec4c4498a1abfc81a3695b |
work_keys_str_mv |
AT grigoriosgeorgolopoulos discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT nikolettapsatha discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT mineoiwata discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT andrewnishida discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT tannishthasom discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT minasyiangou discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT johnastamatoyannopoulos discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT jeffvierstra discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation |
_version_ |
1718407894555164672 |