Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation

Lineage differentiation and commitment is driven by transcription regulators and chromatin changes. Here the authors report daily profiling of chromatin accessibility and transcriptome changes during human erythropoiesis, relating these changes to lineage potential between erythropoiesis and megakar...

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Main Authors:	Grigorios Georgolopoulos, Nikoletta Psatha, Mineo Iwata, Andrew Nishida, Tannishtha Som, Minas Yiangou, John A. Stamatoyannopoulos, Jeff Vierstra
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/6afaac0110ec4c4498a1abfc81a3695b
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id	oai:doaj.org-article:6afaac0110ec4c4498a1abfc81a3695b
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spelling	oai:doaj.org-article:6afaac0110ec4c4498a1abfc81a3695b2021-11-28T12:32:23ZDiscrete regulatory modules instruct hematopoietic lineage commitment and differentiation10.1038/s41467-021-27159-x2041-1723https://doaj.org/article/6afaac0110ec4c4498a1abfc81a3695b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27159-xhttps://doaj.org/toc/2041-1723Lineage differentiation and commitment is driven by transcription regulators and chromatin changes. Here the authors report daily profiling of chromatin accessibility and transcriptome changes during human erythropoiesis, relating these changes to lineage potential between erythropoiesis and megakaryopoieis.Grigorios GeorgolopoulosNikoletta PsathaMineo IwataAndrew NishidaTannishtha SomMinas YiangouJohn A. StamatoyannopoulosJeff VierstraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grigorios Georgolopoulos Nikoletta Psatha Mineo Iwata Andrew Nishida Tannishtha Som Minas Yiangou John A. Stamatoyannopoulos Jeff Vierstra Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
description	Lineage differentiation and commitment is driven by transcription regulators and chromatin changes. Here the authors report daily profiling of chromatin accessibility and transcriptome changes during human erythropoiesis, relating these changes to lineage potential between erythropoiesis and megakaryopoieis.
format	article
author	Grigorios Georgolopoulos Nikoletta Psatha Mineo Iwata Andrew Nishida Tannishtha Som Minas Yiangou John A. Stamatoyannopoulos Jeff Vierstra
author_facet	Grigorios Georgolopoulos Nikoletta Psatha Mineo Iwata Andrew Nishida Tannishtha Som Minas Yiangou John A. Stamatoyannopoulos Jeff Vierstra
author_sort	Grigorios Georgolopoulos
title	Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
title_short	Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
title_full	Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
title_fullStr	Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
title_full_unstemmed	Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
title_sort	discrete regulatory modules instruct hematopoietic lineage commitment and differentiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6afaac0110ec4c4498a1abfc81a3695b
work_keys_str_mv	AT grigoriosgeorgolopoulos discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT nikolettapsatha discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT mineoiwata discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT andrewnishida discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT tannishthasom discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT minasyiangou discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT johnastamatoyannopoulos discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation AT jeffvierstra discreteregulatorymodulesinstructhematopoieticlineagecommitmentanddifferentiation
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Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation

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