Novel opportunities and challenges offered by nanobiomaterials in tissue engineering

Fabrizio GelainBioscience and Biotechnology Department, University of Milan-Bicocca, Milan, ItalyAbstract: Over the last decades, tissue engineering has demonstrated an unquestionable potential to regenerate damaged tissues and organs. Some tissue-engineered solutions recently entered the clinics (e...

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Autor principal:	Fabrizio Gelain
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6afb46147b5f40df94ab6bb1ca1ca85c
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spelling	oai:doaj.org-article:6afb46147b5f40df94ab6bb1ca1ca85c2021-12-02T05:00:27ZNovel opportunities and challenges offered by nanobiomaterials in tissue engineering1176-91141178-2013https://doaj.org/article/6afb46147b5f40df94ab6bb1ca1ca85c2008-08-01T00:00:00Zhttp://www.dovepress.com/novel-opportunities-and-challenges-offered-by-nanobiomaterials-in-tiss-a1969https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Fabrizio GelainBioscience and Biotechnology Department, University of Milan-Bicocca, Milan, ItalyAbstract: Over the last decades, tissue engineering has demonstrated an unquestionable potential to regenerate damaged tissues and organs. Some tissue-engineered solutions recently entered the clinics (eg, artificial bladder, corneal epithelium, engineered skin), but most of the pathologies of interest are still far from being solved. The advent of stem cells opened the door to large-scale production of &ldquo;raw living matter&rdquo; for cell replacement and boosted the overall sector in the last decade. Still reliable synthetic scaffolds fairly resembling the nanostructure of extracellular matrices, showing mechanical properties comparable to those of the tissues to be regenerated and capable of being modularly functionalized with biological active motifs, became feasible only in the last years thanks to newly introduced nanotechnology techniques of material design, synthesis, and characterization. Nanostructured synthetic matrices look to be the next generation scaffolds, opening new powerful pathways for tissue regeneration and introducing new challenges at the same time. We here present a detailed overview of the advantages, applications, and limitations of nanostructured matrices with a focus on both electrospun and self-assembling scaffolds.Keywords: self-assembling peptide, electrospinning, tissue engineering, functionalization Fabrizio GelainDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 415-424 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Fabrizio Gelain Novel opportunities and challenges offered by nanobiomaterials in tissue engineering
description	Fabrizio GelainBioscience and Biotechnology Department, University of Milan-Bicocca, Milan, ItalyAbstract: Over the last decades, tissue engineering has demonstrated an unquestionable potential to regenerate damaged tissues and organs. Some tissue-engineered solutions recently entered the clinics (eg, artificial bladder, corneal epithelium, engineered skin), but most of the pathologies of interest are still far from being solved. The advent of stem cells opened the door to large-scale production of &ldquo;raw living matter&rdquo; for cell replacement and boosted the overall sector in the last decade. Still reliable synthetic scaffolds fairly resembling the nanostructure of extracellular matrices, showing mechanical properties comparable to those of the tissues to be regenerated and capable of being modularly functionalized with biological active motifs, became feasible only in the last years thanks to newly introduced nanotechnology techniques of material design, synthesis, and characterization. Nanostructured synthetic matrices look to be the next generation scaffolds, opening new powerful pathways for tissue regeneration and introducing new challenges at the same time. We here present a detailed overview of the advantages, applications, and limitations of nanostructured matrices with a focus on both electrospun and self-assembling scaffolds.Keywords: self-assembling peptide, electrospinning, tissue engineering, functionalization
format	article
author	Fabrizio Gelain
author_facet	Fabrizio Gelain
author_sort	Fabrizio Gelain
title	Novel opportunities and challenges offered by nanobiomaterials in tissue engineering
title_short	Novel opportunities and challenges offered by nanobiomaterials in tissue engineering
title_full	Novel opportunities and challenges offered by nanobiomaterials in tissue engineering
title_fullStr	Novel opportunities and challenges offered by nanobiomaterials in tissue engineering
title_full_unstemmed	Novel opportunities and challenges offered by nanobiomaterials in tissue engineering
title_sort	novel opportunities and challenges offered by nanobiomaterials in tissue engineering
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/6afb46147b5f40df94ab6bb1ca1ca85c
work_keys_str_mv	AT fabriziogelain novelopportunitiesandchallengesofferedbynanobiomaterialsintissueengineering
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Novel opportunities and challenges offered by nanobiomaterials in tissue engineering

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