Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry

Viruses have been re-engineered for many applications but the ability to build asymmetric capsids in vitro has been lacking. Here, the authors report the design of asymmetric subunits with different growth rates leading to capsids with discrete patches and potential for distinct surface chemistries.

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Autores principales:	Zhongchao Zhao, Joseph Che-Yen Wang, Mi Zhang, Nicholas A. Lyktey, Martin F. Jarrold, Stephen C. Jacobson, Adam Zlotnick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6afcd85b8a4d45b5bcb6913971ca9659
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spelling	oai:doaj.org-article:6afcd85b8a4d45b5bcb6913971ca96592021-12-02T13:57:44ZAsymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry10.1038/s41467-020-20862-12041-1723https://doaj.org/article/6afcd85b8a4d45b5bcb6913971ca96592021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20862-1https://doaj.org/toc/2041-1723Viruses have been re-engineered for many applications but the ability to build asymmetric capsids in vitro has been lacking. Here, the authors report the design of asymmetric subunits with different growth rates leading to capsids with discrete patches and potential for distinct surface chemistries.Zhongchao ZhaoJoseph Che-Yen WangMi ZhangNicholas A. LykteyMartin F. JarroldStephen C. JacobsonAdam ZlotnickNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongchao Zhao Joseph Che-Yen Wang Mi Zhang Nicholas A. Lyktey Martin F. Jarrold Stephen C. Jacobson Adam Zlotnick Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
description	Viruses have been re-engineered for many applications but the ability to build asymmetric capsids in vitro has been lacking. Here, the authors report the design of asymmetric subunits with different growth rates leading to capsids with discrete patches and potential for distinct surface chemistries.
format	article
author	Zhongchao Zhao Joseph Che-Yen Wang Mi Zhang Nicholas A. Lyktey Martin F. Jarrold Stephen C. Jacobson Adam Zlotnick
author_facet	Zhongchao Zhao Joseph Che-Yen Wang Mi Zhang Nicholas A. Lyktey Martin F. Jarrold Stephen C. Jacobson Adam Zlotnick
author_sort	Zhongchao Zhao
title	Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
title_short	Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
title_full	Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
title_fullStr	Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
title_full_unstemmed	Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
title_sort	asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6afcd85b8a4d45b5bcb6913971ca9659
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Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry

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