Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang

Abstract Background HAdV is one of the common pathogens in hospitalized children with acute respiratory infections (ARIs). We aim to describe the clinical and laboratory features, epidemiological characteristics, and HAdV species and/or types of inpatients with HAdV respiratory infections. Methods R...

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Autores principales:	Caiyun Wang, Juanjuan Liu, Yumei Mi, Jing Chen, Jing Bi, Yinghu Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Human adenovirus Acute respiratory infections Molecular epidemiology Children Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/6afe0aacfe83472cba11dd63d55e025d
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spelling	oai:doaj.org-article:6afe0aacfe83472cba11dd63d55e025d2021-12-05T12:03:05ZClinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang10.1186/s12985-021-01705-x1743-422Xhttps://doaj.org/article/6afe0aacfe83472cba11dd63d55e025d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01705-xhttps://doaj.org/toc/1743-422XAbstract Background HAdV is one of the common pathogens in hospitalized children with acute respiratory infections (ARIs). We aim to describe the clinical and laboratory features, epidemiological characteristics, and HAdV species and/or types of inpatients with HAdV respiratory infections. Methods Respiratory samples were gathered from inpatients diagnosed ARIs in Children’s Hospital, Zhejiang University School of Medicine, and were detected by using Direct Immunofluorescence Assay from 2018 to 2019. PCR amplification and sequencing of the hypervariable zone of hexon gene were used for genotyping. The clinical and laboratory features, and HAdV genotyping, and epidemiological characteristic analysis were retrospectively performed. Results Of 7072 samples collected, 488 were identified as HAdV-positive. The overall detection rate was 6.9%. The peaked detection rate was 14.1% in January 2019. HAdV-positive cases with ARIs mainly appeared in winter. The detection rate was highest among children between 6 months and 2 years (8.7%, 123/1408). Clinical diagnosis included pneumonia (70.3%, 343/488), bronchitis (7.0%, 34/488) and acute upper respiratory tract infection (22.7%, 111/488). The common clinical manifestations were fever (93.4%, 456/488), cough (94.7%, 462/488), wheezing (26.2%, 128/488), and shortness of breath (14.8%, 72/488). 213 (43.6%) cases had co-infection and 138 (28.3%) cases had extrapulmonary symptoms. 96(19.7%) cases had intrapulmonary and intrathoracic complications.78 (16.0%) had an underlying condition, most of which were congenital heart diseases (20.5%, 16/78). The proportions of hyperpyrexia, duration of fever > 10 days, severe pneumonia, and wheezing in the co-infection group were remarkably higher than those in HAdV single-infection group (all p < 0.05). The proportions of duration of hospitalization, duration of fever > 10 days, wheezing, shortness of breath, change in level of consciousness, serosal fluids, extrapulmonary symptoms, co-infections and underlying diseases were significantly higher in severe pneumonia group than those in the mild pneumonia group (all p < 0.05). Four HAdV species were successfully identified in 155 cases and presented by 8 genotypes. HAdV-B3 (56.1%, 87/155) and HAdV -B7 (31.0%, 48/155) were the most predominant detected types and occurred commonly in different severity groups (p = 0.000), while, HAdV-B55 was detected only in the severe group. HAdV-B7’s detection rate in the severe pneumonia group was significantly higher than the non-severe pneumonia group. Conclusion HAdV detection rate is related to age and season. Bronchopneumonia accounts for about 70% HAdV-positive inpatients. The common clinical manifestations include hyperpyrexia, cough, wheezing, and shortness of breath. HAdV-B3 and HAdV-B7 are the most common types in children diagnosed with respiration infections.Caiyun WangJuanjuan LiuYumei MiJing ChenJing BiYinghu ChenBMCarticleHuman adenovirusAcute respiratory infectionsMolecular epidemiologyChildrenInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Human adenovirus Acute respiratory infections Molecular epidemiology Children Infectious and parasitic diseases RC109-216
spellingShingle	Human adenovirus Acute respiratory infections Molecular epidemiology Children Infectious and parasitic diseases RC109-216 Caiyun Wang Juanjuan Liu Yumei Mi Jing Chen Jing Bi Yinghu Chen Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang
description	Abstract Background HAdV is one of the common pathogens in hospitalized children with acute respiratory infections (ARIs). We aim to describe the clinical and laboratory features, epidemiological characteristics, and HAdV species and/or types of inpatients with HAdV respiratory infections. Methods Respiratory samples were gathered from inpatients diagnosed ARIs in Children’s Hospital, Zhejiang University School of Medicine, and were detected by using Direct Immunofluorescence Assay from 2018 to 2019. PCR amplification and sequencing of the hypervariable zone of hexon gene were used for genotyping. The clinical and laboratory features, and HAdV genotyping, and epidemiological characteristic analysis were retrospectively performed. Results Of 7072 samples collected, 488 were identified as HAdV-positive. The overall detection rate was 6.9%. The peaked detection rate was 14.1% in January 2019. HAdV-positive cases with ARIs mainly appeared in winter. The detection rate was highest among children between 6 months and 2 years (8.7%, 123/1408). Clinical diagnosis included pneumonia (70.3%, 343/488), bronchitis (7.0%, 34/488) and acute upper respiratory tract infection (22.7%, 111/488). The common clinical manifestations were fever (93.4%, 456/488), cough (94.7%, 462/488), wheezing (26.2%, 128/488), and shortness of breath (14.8%, 72/488). 213 (43.6%) cases had co-infection and 138 (28.3%) cases had extrapulmonary symptoms. 96(19.7%) cases had intrapulmonary and intrathoracic complications.78 (16.0%) had an underlying condition, most of which were congenital heart diseases (20.5%, 16/78). The proportions of hyperpyrexia, duration of fever > 10 days, severe pneumonia, and wheezing in the co-infection group were remarkably higher than those in HAdV single-infection group (all p < 0.05). The proportions of duration of hospitalization, duration of fever > 10 days, wheezing, shortness of breath, change in level of consciousness, serosal fluids, extrapulmonary symptoms, co-infections and underlying diseases were significantly higher in severe pneumonia group than those in the mild pneumonia group (all p < 0.05). Four HAdV species were successfully identified in 155 cases and presented by 8 genotypes. HAdV-B3 (56.1%, 87/155) and HAdV -B7 (31.0%, 48/155) were the most predominant detected types and occurred commonly in different severity groups (p = 0.000), while, HAdV-B55 was detected only in the severe group. HAdV-B7’s detection rate in the severe pneumonia group was significantly higher than the non-severe pneumonia group. Conclusion HAdV detection rate is related to age and season. Bronchopneumonia accounts for about 70% HAdV-positive inpatients. The common clinical manifestations include hyperpyrexia, cough, wheezing, and shortness of breath. HAdV-B3 and HAdV-B7 are the most common types in children diagnosed with respiration infections.
format	article
author	Caiyun Wang Juanjuan Liu Yumei Mi Jing Chen Jing Bi Yinghu Chen
author_facet	Caiyun Wang Juanjuan Liu Yumei Mi Jing Chen Jing Bi Yinghu Chen
author_sort	Caiyun Wang
title	Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang
title_short	Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang
title_full	Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang
title_fullStr	Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang
title_full_unstemmed	Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang
title_sort	clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in zhejiang
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6afe0aacfe83472cba11dd63d55e025d
work_keys_str_mv	AT caiyunwang clinicalfeaturesandepidemiologicalanalysisofrespiratoryhumanadenovirusinfectioninhospitalizedchildrenacrosssectionalstudyinzhejiang AT juanjuanliu clinicalfeaturesandepidemiologicalanalysisofrespiratoryhumanadenovirusinfectioninhospitalizedchildrenacrosssectionalstudyinzhejiang AT yumeimi clinicalfeaturesandepidemiologicalanalysisofrespiratoryhumanadenovirusinfectioninhospitalizedchildrenacrosssectionalstudyinzhejiang AT jingchen clinicalfeaturesandepidemiologicalanalysisofrespiratoryhumanadenovirusinfectioninhospitalizedchildrenacrosssectionalstudyinzhejiang AT jingbi clinicalfeaturesandepidemiologicalanalysisofrespiratoryhumanadenovirusinfectioninhospitalizedchildrenacrosssectionalstudyinzhejiang AT yinghuchen clinicalfeaturesandepidemiologicalanalysisofrespiratoryhumanadenovirusinfectioninhospitalizedchildrenacrosssectionalstudyinzhejiang
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Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang

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