Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study

Mahima Jhingan,1 Abhilash Goud,1 Hari Kumar Peguda,1 Mitali Khodani,1 Jeffrey K Luttrull,2 Jay Chhablani1 1L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India; 2Ventura County Retina Vitreous Medical Group, CA, USA Aim: To compare the outcomes of subthreshold microsecond (STM) and...

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Autores principales:	Jhingan M, Goud A, Peguda HK, Khodani M, Luttrull JK, Chhablani J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Panretinal photocoagulation Diabetic Retinopathy Proliferative Diabetic Retinopathy Micropulse laser Microsecond laser Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6b0174734d124675b9b806d87c48f0ef
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spelling	oai:doaj.org-article:6b0174734d124675b9b806d87c48f0ef2021-12-02T05:34:58ZSubthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study1177-5483https://doaj.org/article/6b0174734d124675b9b806d87c48f0ef2018-01-01T00:00:00Zhttps://www.dovepress.com/subthreshold-microsecond-laser-for-proliferative-diabetic-retinopathy--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mahima Jhingan,1 Abhilash Goud,1 Hari Kumar Peguda,1 Mitali Khodani,1 Jeffrey K Luttrull,2 Jay Chhablani1 1L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India; 2Ventura County Retina Vitreous Medical Group, CA, USA Aim: To compare the outcomes of subthreshold microsecond (STM) and continuous-wave laser (CWL) panretinal photocoagulation (PRP).Methods: In this randomized, prospective, pilot study, 20 eyes of 10 subjects with symmetric severe non-proliferative (NPDR) or low-risk proliferative diabetic retinopathy (PDR) were included. Each eye of the subject was randomized into either CWL or STM PRP group. Patients were evaluated at baseline and at months 3, 6, and 9 with color fundus photographs and visual field tests at each visit; however, electroretinography (ERG) was conducted at baseline and at month 9. The primary outcome measure was the difference in disease progression between the groups. Secondary outcome measures included change in visual acuity, contrast visual acuity, retinal sensitivity on visual field test, and change in ERG parameters.Results: During the 9-month follow-up, one eye of the STM group progressed to vitreous hemorrhage at the month 6 follow-up and required rescue conventional laser. The CWL group showed a drop in low-contrast visual acuity, visual field index, and scotopic b/a ratio in comparison to the STM group, although the difference was statistically insignificant (p>0.05).Conclusion: This prospective pilot study proposes microsecond PRP is non-inferior to CWL PRP and could be an alternative to CWL PRP to avoid associated complications in cases of severe NPDR and early PDR. Keywords: panretinal photocoagulation, diabetic retinopathy, proliferative diabetic retinopathy, micropulse laser, microsecond laser Jhingan MGoud APeguda HKKhodani MLuttrull JKChhablani JDove Medical PressarticlePanretinal photocoagulationDiabetic RetinopathyProliferative Diabetic RetinopathyMicropulse laserMicrosecond laserOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 141-145 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Panretinal photocoagulation Diabetic Retinopathy Proliferative Diabetic Retinopathy Micropulse laser Microsecond laser Ophthalmology RE1-994
spellingShingle	Panretinal photocoagulation Diabetic Retinopathy Proliferative Diabetic Retinopathy Micropulse laser Microsecond laser Ophthalmology RE1-994 Jhingan M Goud A Peguda HK Khodani M Luttrull JK Chhablani J Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
description	Mahima Jhingan,1 Abhilash Goud,1 Hari Kumar Peguda,1 Mitali Khodani,1 Jeffrey K Luttrull,2 Jay Chhablani1 1L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India; 2Ventura County Retina Vitreous Medical Group, CA, USA Aim: To compare the outcomes of subthreshold microsecond (STM) and continuous-wave laser (CWL) panretinal photocoagulation (PRP).Methods: In this randomized, prospective, pilot study, 20 eyes of 10 subjects with symmetric severe non-proliferative (NPDR) or low-risk proliferative diabetic retinopathy (PDR) were included. Each eye of the subject was randomized into either CWL or STM PRP group. Patients were evaluated at baseline and at months 3, 6, and 9 with color fundus photographs and visual field tests at each visit; however, electroretinography (ERG) was conducted at baseline and at month 9. The primary outcome measure was the difference in disease progression between the groups. Secondary outcome measures included change in visual acuity, contrast visual acuity, retinal sensitivity on visual field test, and change in ERG parameters.Results: During the 9-month follow-up, one eye of the STM group progressed to vitreous hemorrhage at the month 6 follow-up and required rescue conventional laser. The CWL group showed a drop in low-contrast visual acuity, visual field index, and scotopic b/a ratio in comparison to the STM group, although the difference was statistically insignificant (p>0.05).Conclusion: This prospective pilot study proposes microsecond PRP is non-inferior to CWL PRP and could be an alternative to CWL PRP to avoid associated complications in cases of severe NPDR and early PDR. Keywords: panretinal photocoagulation, diabetic retinopathy, proliferative diabetic retinopathy, micropulse laser, microsecond laser
format	article
author	Jhingan M Goud A Peguda HK Khodani M Luttrull JK Chhablani J
author_facet	Jhingan M Goud A Peguda HK Khodani M Luttrull JK Chhablani J
author_sort	Jhingan M
title	Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
title_short	Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
title_full	Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
title_fullStr	Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
title_full_unstemmed	Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
title_sort	subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6b0174734d124675b9b806d87c48f0ef
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_version_	1718400355605151744

Subthreshold microsecond laser for proliferative diabetic retinopathy: a randomized pilot study

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