Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer

Abstract Because of the complex etiology, the treatment of gastric cancer is a formidable challenge for contemporary medical. The current treatment method focuses on traditional surgical procedures, supplemented by other treatments. Among these other treatments, Traditional Chinese Medicine (TCM) pl...

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Autores principales:	Lulu Zhang, Yue Xiao, Ruijie Yang, Siyi Wang, ShuangXin Ma, Jianling Liu, Wei Xiao, Yonghua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b055e6d33e54aa0a592e6436e9bf39b
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spelling	oai:doaj.org-article:6b055e6d33e54aa0a592e6436e9bf39b2021-11-14T12:17:35ZSystems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer10.1038/s41598-021-01535-52045-2322https://doaj.org/article/6b055e6d33e54aa0a592e6436e9bf39b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01535-5https://doaj.org/toc/2045-2322Abstract Because of the complex etiology, the treatment of gastric cancer is a formidable challenge for contemporary medical. The current treatment method focuses on traditional surgical procedures, supplemented by other treatments. Among these other treatments, Traditional Chinese Medicine (TCM) plays an important role. Here, we used the systems pharmacology approach to reveal the potential molecular mechanism of PRGRC on gastric cancer which composes of Pinellia ternata (Thunb.) Breit., Rheum palmatum L., Gentiana scabra Bunge, Radix Aucklandiae and Citrus aurantium L. This approach combines pharmacokinetics analysis with pharmacodynamics evaluation for the active compounds screening, targets prediction and pathways assessing. Firstly, through pharmacokinetic evaluation and target prediction models, 83 potential compounds and 184 gastric cancer-related targets were screened out. Then, the results of network analysis suggested that the targets of PRGRC were mainly involved two aspects: apoptosis and inflammation. Finally, we verified the reliability of the above analysis at the cellular level by using naringenin and luteolin with good pharmacokinetic activity as representative compounds. Overall, we found that PRGRC could influence the development of gastric cancer from a multi-scale perspective. This study provided a new direction for analyzing the mechanism of TCM.Lulu ZhangYue XiaoRuijie YangSiyi WangShuangXin MaJianling LiuWei XiaoYonghua WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lulu Zhang Yue Xiao Ruijie Yang Siyi Wang ShuangXin Ma Jianling Liu Wei Xiao Yonghua Wang Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer
description	Abstract Because of the complex etiology, the treatment of gastric cancer is a formidable challenge for contemporary medical. The current treatment method focuses on traditional surgical procedures, supplemented by other treatments. Among these other treatments, Traditional Chinese Medicine (TCM) plays an important role. Here, we used the systems pharmacology approach to reveal the potential molecular mechanism of PRGRC on gastric cancer which composes of Pinellia ternata (Thunb.) Breit., Rheum palmatum L., Gentiana scabra Bunge, Radix Aucklandiae and Citrus aurantium L. This approach combines pharmacokinetics analysis with pharmacodynamics evaluation for the active compounds screening, targets prediction and pathways assessing. Firstly, through pharmacokinetic evaluation and target prediction models, 83 potential compounds and 184 gastric cancer-related targets were screened out. Then, the results of network analysis suggested that the targets of PRGRC were mainly involved two aspects: apoptosis and inflammation. Finally, we verified the reliability of the above analysis at the cellular level by using naringenin and luteolin with good pharmacokinetic activity as representative compounds. Overall, we found that PRGRC could influence the development of gastric cancer from a multi-scale perspective. This study provided a new direction for analyzing the mechanism of TCM.
format	article
author	Lulu Zhang Yue Xiao Ruijie Yang Siyi Wang ShuangXin Ma Jianling Liu Wei Xiao Yonghua Wang
author_facet	Lulu Zhang Yue Xiao Ruijie Yang Siyi Wang ShuangXin Ma Jianling Liu Wei Xiao Yonghua Wang
author_sort	Lulu Zhang
title	Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer
title_short	Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer
title_full	Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer
title_fullStr	Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer
title_full_unstemmed	Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer
title_sort	systems pharmacology to reveal multi-scale mechanisms of traditional chinese medicine for gastric cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b055e6d33e54aa0a592e6436e9bf39b
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Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer

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