Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites

Abstract Box C/D ribonucleoprotein complexes are RNA-guided methyltransferases that methylate the ribose 2’-OH of RNA. The central ‘guide RNA’ has box C and D motifs at its ends, which are crucial for activity. Archaeal guide RNAs have a second box C’/D’ motif pair that is also essential for functio...

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Bibliographic Details
Main Authors: Simone Höfler, Peer Lukat, Wulf Blankenfeldt, Teresa Carlomagno
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/6b06d43f8c7b44b0bfbeb0e72c36370a
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