Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

Stockdale et al. assess longitudinal faecal virome changes in a rat model of Parkinson’s Disease (PD) in which either monomeric or preformed fibrils (PFF) of α-synuclein were administered directly into their enteric nervous system. They demonstrate that virome alterations are potentially reactive to...

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Autores principales:	Stephen R. Stockdale, Lorraine A. Draper, Sarah M. O’Donovan, Wiley Barton, Orla O’Sullivan, Laura A. Volpicelli-Daley, Aideen M. Sullivan, Cora O’Neill, Colin Hill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6b087a30a51f4803909780c52c0c4ff7
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spelling	oai:doaj.org-article:6b087a30a51f4803909780c52c0c4ff72021-12-02T18:51:13ZAlpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease10.1038/s42003-021-02666-12399-3642https://doaj.org/article/6b087a30a51f4803909780c52c0c4ff72021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02666-1https://doaj.org/toc/2399-3642Stockdale et al. assess longitudinal faecal virome changes in a rat model of Parkinson’s Disease (PD) in which either monomeric or preformed fibrils (PFF) of α-synuclein were administered directly into their enteric nervous system. They demonstrate that virome alterations are potentially reactive to host α-synuclein changes that are associated with PD development.Stephen R. StockdaleLorraine A. DraperSarah M. O’DonovanWiley BartonOrla O’SullivanLaura A. Volpicelli-DaleyAideen M. SullivanCora O’NeillColin HillNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Stephen R. Stockdale Lorraine A. Draper Sarah M. O’Donovan Wiley Barton Orla O’Sullivan Laura A. Volpicelli-Daley Aideen M. Sullivan Cora O’Neill Colin Hill Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
description	Stockdale et al. assess longitudinal faecal virome changes in a rat model of Parkinson’s Disease (PD) in which either monomeric or preformed fibrils (PFF) of α-synuclein were administered directly into their enteric nervous system. They demonstrate that virome alterations are potentially reactive to host α-synuclein changes that are associated with PD development.
format	article
author	Stephen R. Stockdale Lorraine A. Draper Sarah M. O’Donovan Wiley Barton Orla O’Sullivan Laura A. Volpicelli-Daley Aideen M. Sullivan Cora O’Neill Colin Hill
author_facet	Stephen R. Stockdale Lorraine A. Draper Sarah M. O’Donovan Wiley Barton Orla O’Sullivan Laura A. Volpicelli-Daley Aideen M. Sullivan Cora O’Neill Colin Hill
author_sort	Stephen R. Stockdale
title	Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
title_short	Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
title_full	Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
title_fullStr	Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
title_full_unstemmed	Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
title_sort	alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b087a30a51f4803909780c52c0c4ff7
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Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

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