Nanomaterial-Based Tumor Photothermal Immunotherapy

Peng Xu, Feng Liang The State Key Laboratory of Refractories and Metallurgy, Coal Conversion and New Carbon Materials Hubei Key Laboratory, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of ChinaCorrespondence: Feng...

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Autores principales:	Xu P, Liang F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanomaterials photothermal therapy tumor microenvironment immunogenic cell death photothermal immunotherapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b0d4907eb014e4a9d5414554dc3463b
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spelling	oai:doaj.org-article:6b0d4907eb014e4a9d5414554dc3463b2021-12-02T14:59:19ZNanomaterial-Based Tumor Photothermal Immunotherapy1178-2013https://doaj.org/article/6b0d4907eb014e4a9d5414554dc3463b2020-11-01T00:00:00Zhttps://www.dovepress.com/nanomaterial-based-tumor-photothermal-immunotherapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Peng Xu, Feng Liang The State Key Laboratory of Refractories and Metallurgy, Coal Conversion and New Carbon Materials Hubei Key Laboratory, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of ChinaCorrespondence: Feng Liang Email feng_liang@whu.edu.cnAbstract: In recent years, photothermal therapy (PTT) particularly nanomaterial-based PTT is a promising therapeutic modality and technique for cancer tumor ablation. In addition to killing tumor cells directly through heat, PTT also can induce immunogenic cell death (ICD) to activate the whole-body anti-tumor immune response, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. When used in combination with immunotherapy, the efficacy of nanomaterial-based PTT can be improved. This article summarized the mechanism of nanomaterial-based PTT against cancer and how nanomaterial-based PTT impacts the tumor microenvironment and induces an immune response. Moreover, we reviewed recent advances of nanomaterial-based photothermal immunotherapy and discussed challenges and future outlook.Keywords: nanomaterials, cell death mechanism of PTT, tumor microenvironment, immunogenic cell death, photothermal immunotherapyXu PLiang FDove Medical Pressarticlenanomaterialsphotothermal therapytumor microenvironmentimmunogenic cell deathphotothermal immunotherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9159-9180 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomaterials photothermal therapy tumor microenvironment immunogenic cell death photothermal immunotherapy Medicine (General) R5-920
spellingShingle	nanomaterials photothermal therapy tumor microenvironment immunogenic cell death photothermal immunotherapy Medicine (General) R5-920 Xu P Liang F Nanomaterial-Based Tumor Photothermal Immunotherapy
description	Peng Xu, Feng Liang The State Key Laboratory of Refractories and Metallurgy, Coal Conversion and New Carbon Materials Hubei Key Laboratory, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of ChinaCorrespondence: Feng Liang Email feng_liang@whu.edu.cnAbstract: In recent years, photothermal therapy (PTT) particularly nanomaterial-based PTT is a promising therapeutic modality and technique for cancer tumor ablation. In addition to killing tumor cells directly through heat, PTT also can induce immunogenic cell death (ICD) to activate the whole-body anti-tumor immune response, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. When used in combination with immunotherapy, the efficacy of nanomaterial-based PTT can be improved. This article summarized the mechanism of nanomaterial-based PTT against cancer and how nanomaterial-based PTT impacts the tumor microenvironment and induces an immune response. Moreover, we reviewed recent advances of nanomaterial-based photothermal immunotherapy and discussed challenges and future outlook.Keywords: nanomaterials, cell death mechanism of PTT, tumor microenvironment, immunogenic cell death, photothermal immunotherapy
format	article
author	Xu P Liang F
author_facet	Xu P Liang F
author_sort	Xu P
title	Nanomaterial-Based Tumor Photothermal Immunotherapy
title_short	Nanomaterial-Based Tumor Photothermal Immunotherapy
title_full	Nanomaterial-Based Tumor Photothermal Immunotherapy
title_fullStr	Nanomaterial-Based Tumor Photothermal Immunotherapy
title_full_unstemmed	Nanomaterial-Based Tumor Photothermal Immunotherapy
title_sort	nanomaterial-based tumor photothermal immunotherapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6b0d4907eb014e4a9d5414554dc3463b
work_keys_str_mv	AT xup nanomaterialbasedtumorphotothermalimmunotherapy AT liangf nanomaterialbasedtumorphotothermalimmunotherapy
_version_	1718389206297870336

Nanomaterial-Based Tumor Photothermal Immunotherapy

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