Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.

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Autores principales:	Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8
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spelling	oai:doaj.org-article:6b10bf22d1cf44e59fc4465f802a33e82021-12-02T17:32:49ZRegulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin10.1038/s41467-018-07714-92041-1723https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e82018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07714-9https://doaj.org/toc/2041-1723Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.Eileen McNeillElena StylianouMark J. CrabtreeRachel Harrington-KandtAnna-Lena KolbMarina DiotalleviAshley B. HalePaulo BettencourtRachel TannerMatthew K. O’SheaMagali MatsumiyaHelen LockstoneJulius MüllerHelen A. FletcherDavid R. GreavesHelen McShaneKeith M. ChannonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eileen McNeill Elena Stylianou Mark J. Crabtree Rachel Harrington-Kandt Anna-Lena Kolb Marina Diotallevi Ashley B. Hale Paulo Bettencourt Rachel Tanner Matthew K. O’Shea Magali Matsumiya Helen Lockstone Julius Müller Helen A. Fletcher David R. Greaves Helen McShane Keith M. Channon Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
description	Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.
format	article
author	Eileen McNeill Elena Stylianou Mark J. Crabtree Rachel Harrington-Kandt Anna-Lena Kolb Marina Diotallevi Ashley B. Hale Paulo Bettencourt Rachel Tanner Matthew K. O’Shea Magali Matsumiya Helen Lockstone Julius Müller Helen A. Fletcher David R. Greaves Helen McShane Keith M. Channon
author_facet	Eileen McNeill Elena Stylianou Mark J. Crabtree Rachel Harrington-Kandt Anna-Lena Kolb Marina Diotallevi Ashley B. Hale Paulo Bettencourt Rachel Tanner Matthew K. O’Shea Magali Matsumiya Helen Lockstone Julius Müller Helen A. Fletcher David R. Greaves Helen McShane Keith M. Channon
author_sort	Eileen McNeill
title	Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
title_short	Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
title_full	Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
title_fullStr	Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
title_full_unstemmed	Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
title_sort	regulation of mycobacterial infection by macrophage gch1 and tetrahydrobiopterin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8
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Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

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