A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma

A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma

Abstract Background Antibody-based therapies targeting CD38 are currently used as single agents as well as in combination regimens for multiple myeloma, a malignant plasma cell disorder. In this study, we aimed to develop anti-CD38 single-domain antibodies (sdAbs) that can be used to trace CD38+ tum...

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Autores principales: Elodie Duray, Margaux Lejeune, Frederic Baron, Yves Beguin, Nick Devoogdt, Ahmet Krasniqi, Yoline Lauwers, Yong Juan Zhao, Matthias D’Huyvetter, Mireille Dumoulin, Jo Caers
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Multiple myeloma
CD38
Theranostic
Single-domain antibody
Nanobody
Radio-immunotherapy
Diseases of the blood and blood-forming organs
RC633-647.5
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/6b141013e0604fe3b0f374aa12371db3
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https://doaj.org/article/6b141013e0604fe3b0f374aa12371db3

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