A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma

Abstract Background Antibody-based therapies targeting CD38 are currently used as single agents as well as in combination regimens for multiple myeloma, a malignant plasma cell disorder. In this study, we aimed to develop anti-CD38 single-domain antibodies (sdAbs) that can be used to trace CD38+ tum...

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Autores principales:	Elodie Duray, Margaux Lejeune, Frederic Baron, Yves Beguin, Nick Devoogdt, Ahmet Krasniqi, Yoline Lauwers, Yong Juan Zhao, Matthias D’Huyvetter, Mireille Dumoulin, Jo Caers
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Multiple myeloma CD38 Theranostic Single-domain antibody Nanobody Radio-immunotherapy Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6b141013e0604fe3b0f374aa12371db3
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A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma

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