The influence of human genetic variation on Epstein–Barr virus sequence diversity

Abstract Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sina Rüeger, Christian Hammer, Alexis Loetscher, Paul J. McLaren, Dylan Lawless, Olivier Naret, Daniel P. Depledge, Sofia Morfopoulou, Judith Breuer, Evgeny Zdobnov, Jacques Fellay, the Swiss HIV Cohort Study
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b142b84091a44b1a57768ff6d6d4c51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6b142b84091a44b1a57768ff6d6d4c51
record_format	dspace
spelling	oai:doaj.org-article:6b142b84091a44b1a57768ff6d6d4c512021-12-02T11:35:52ZThe influence of human genetic variation on Epstein–Barr virus sequence diversity10.1038/s41598-021-84070-72045-2322https://doaj.org/article/6b142b84091a44b1a57768ff6d6d4c512021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84070-7https://doaj.org/toc/2045-2322Abstract Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on the EBV sequence, we jointly analyzed paired viral and human genomic data from 268 HIV-coinfected individuals with CD4 + T cell count < 200/mm3 and elevated EBV viremia. We hypothesized that the reactivated virus circulating in these patients could carry sequence variants acquired during primary EBV infection, thereby providing a snapshot of early adaptation to the pressure exerted on EBV by the individual immune response. We searched for associations between host and pathogen genetic variants, taking into account human and EBV population structure. Our analyses revealed significant associations between human and EBV sequence variation. Three polymorphic regions in the human genome were found to be associated with EBV variation: one at the amino acid level (BRLF1:p.Lys316Glu); and two at the gene level (burden testing of rare variants in BALF5 and BBRF1). Our findings confirm that jointly analyzing host and pathogen genomes can identify sites of genomic interactions, which could help dissect pathogenic mechanisms and suggest new therapeutic avenues.Sina RüegerChristian HammerAlexis LoetscherPaul J. McLarenDylan LawlessOlivier NaretDaniel P. DepledgeSofia MorfopoulouJudith BreuerEvgeny ZdobnovJacques Fellaythe Swiss HIV Cohort StudyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sina Rüeger Christian Hammer Alexis Loetscher Paul J. McLaren Dylan Lawless Olivier Naret Daniel P. Depledge Sofia Morfopoulou Judith Breuer Evgeny Zdobnov Jacques Fellay the Swiss HIV Cohort Study The influence of human genetic variation on Epstein–Barr virus sequence diversity
description	Abstract Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on the EBV sequence, we jointly analyzed paired viral and human genomic data from 268 HIV-coinfected individuals with CD4 + T cell count < 200/mm3 and elevated EBV viremia. We hypothesized that the reactivated virus circulating in these patients could carry sequence variants acquired during primary EBV infection, thereby providing a snapshot of early adaptation to the pressure exerted on EBV by the individual immune response. We searched for associations between host and pathogen genetic variants, taking into account human and EBV population structure. Our analyses revealed significant associations between human and EBV sequence variation. Three polymorphic regions in the human genome were found to be associated with EBV variation: one at the amino acid level (BRLF1:p.Lys316Glu); and two at the gene level (burden testing of rare variants in BALF5 and BBRF1). Our findings confirm that jointly analyzing host and pathogen genomes can identify sites of genomic interactions, which could help dissect pathogenic mechanisms and suggest new therapeutic avenues.
format	article
author	Sina Rüeger Christian Hammer Alexis Loetscher Paul J. McLaren Dylan Lawless Olivier Naret Daniel P. Depledge Sofia Morfopoulou Judith Breuer Evgeny Zdobnov Jacques Fellay the Swiss HIV Cohort Study
author_facet	Sina Rüeger Christian Hammer Alexis Loetscher Paul J. McLaren Dylan Lawless Olivier Naret Daniel P. Depledge Sofia Morfopoulou Judith Breuer Evgeny Zdobnov Jacques Fellay the Swiss HIV Cohort Study
author_sort	Sina Rüeger
title	The influence of human genetic variation on Epstein–Barr virus sequence diversity
title_short	The influence of human genetic variation on Epstein–Barr virus sequence diversity
title_full	The influence of human genetic variation on Epstein–Barr virus sequence diversity
title_fullStr	The influence of human genetic variation on Epstein–Barr virus sequence diversity
title_full_unstemmed	The influence of human genetic variation on Epstein–Barr virus sequence diversity
title_sort	influence of human genetic variation on epstein–barr virus sequence diversity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b142b84091a44b1a57768ff6d6d4c51
work_keys_str_mv	AT sinarueger theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT christianhammer theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT alexisloetscher theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT pauljmclaren theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT dylanlawless theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT oliviernaret theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT danielpdepledge theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT sofiamorfopoulou theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT judithbreuer theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT evgenyzdobnov theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT jacquesfellay theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT theswisshivcohortstudy theinfluenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT sinarueger influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT christianhammer influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT alexisloetscher influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT pauljmclaren influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT dylanlawless influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT oliviernaret influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT danielpdepledge influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT sofiamorfopoulou influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT judithbreuer influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT evgenyzdobnov influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT jacquesfellay influenceofhumangeneticvariationonepsteinbarrvirussequencediversity AT theswisshivcohortstudy influenceofhumangeneticvariationonepsteinbarrvirussequencediversity
_version_	1718395824133636096

The influence of human genetic variation on Epstein–Barr virus sequence diversity

Ejemplares similares