IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS

Latent rhinosinusitis proceeds without facial pain symptoms. Immune deficiency plays a leading role in pathogenesis of the disease latency. Substance P seems to be a universal mediator of painful irritation and inflammation. The objective of our study was to determine effectiveness of therapies in p...

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Autores principales:	I. V. Stagnieva, A. S. Simbirtsev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	immune profile immunodeficiency cytokines rhinosinusitis substance p facial pain Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6b159a9a5ef24e3ea2d6337ec6d1b52b
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spelling	oai:doaj.org-article:6b159a9a5ef24e3ea2d6337ec6d1b52b2021-11-18T08:03:45ZIMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS1563-06252313-741X10.15789/1563-0625-2015-5-423-430https://doaj.org/article/6b159a9a5ef24e3ea2d6337ec6d1b52b2015-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/921https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XLatent rhinosinusitis proceeds without facial pain symptoms. Immune deficiency plays a leading role in pathogenesis of the disease latency. Substance P seems to be a universal mediator of painful irritation and inflammation. The objective of our study was to determine effectiveness of therapies in patients with latent rhinosinusitis, in terms of substance P levels.We treated 148 patients with rhinosinusitis, being free of local pains. All the patients underwent clinical and laboratory examination, including immune profile assessment, measurements of serum cytokines IL-1β, IL-4, IL-6, IL-8, IL-10, TNFα, IFNγ, and substance P. To correct a secondary immunodeficiency, the standard treatment of rhinosinusitis in a subgroup of the patients was accomplished by immunomodulatory drugs from the first day of therapy. The latter drugs were avoided for the rest of study group. Efficacy of treatment was evaluated by clinical signs and laboratory parameters on day 7 of the medication. Pre-treatment levels of substance P were determined in all the patients with latent clinical course and lack of pain symptoms. Low substance P levels (< 100 pg /ml) were considered as indications for immunomodulatory therapy, due to immune deficiency confirmed by the cytokine imbalance. Choice of a specific drug was dependent on immunopathogenesis, i.e., for catarrhal rhinosinusitis and deficiency of cellular immunity, we administered IFN-ES-lipint; in cases of purulent rhinosinusitis, Likopid was applied. The patients treated with immunomodulatory drugs showed improvement of immune indexes by the 7th day of treatment, along with return of substance P levels to control values typical to healthy persons. Among patients with low substance P levels and immune deficiency (without immunomodulatory treatment), the immune parameters and substance P levels did not exhibit any sufficient changes over time.Low contents of substance P (SP ≤ 100 pg /ml) in blood serum in pain-free patients with latent rhinosinusitis are indicative of immune deficiency and may serve as an indication for immune modulation therapy. Individual selection of the pathogenetically proven schedule therapy, when treating patients with latent (painless) rhinosinusitis may result into effective prevention of severe inflammation, normalization of immune response, prevention of a protracted disease course, and appropriate complications, as well as shortening of treatment terms to 8-10 daysI. V. StagnievaA. S. SimbirtsevSPb RAACIarticleimmune profileimmunodeficiencycytokinesrhinosinusitissubstance pfacial painImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 5, Pp 423-430 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune profile immunodeficiency cytokines rhinosinusitis substance p facial pain Immunologic diseases. Allergy RC581-607
spellingShingle	immune profile immunodeficiency cytokines rhinosinusitis substance p facial pain Immunologic diseases. Allergy RC581-607 I. V. Stagnieva A. S. Simbirtsev IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS
description	Latent rhinosinusitis proceeds without facial pain symptoms. Immune deficiency plays a leading role in pathogenesis of the disease latency. Substance P seems to be a universal mediator of painful irritation and inflammation. The objective of our study was to determine effectiveness of therapies in patients with latent rhinosinusitis, in terms of substance P levels.We treated 148 patients with rhinosinusitis, being free of local pains. All the patients underwent clinical and laboratory examination, including immune profile assessment, measurements of serum cytokines IL-1β, IL-4, IL-6, IL-8, IL-10, TNFα, IFNγ, and substance P. To correct a secondary immunodeficiency, the standard treatment of rhinosinusitis in a subgroup of the patients was accomplished by immunomodulatory drugs from the first day of therapy. The latter drugs were avoided for the rest of study group. Efficacy of treatment was evaluated by clinical signs and laboratory parameters on day 7 of the medication. Pre-treatment levels of substance P were determined in all the patients with latent clinical course and lack of pain symptoms. Low substance P levels (< 100 pg /ml) were considered as indications for immunomodulatory therapy, due to immune deficiency confirmed by the cytokine imbalance. Choice of a specific drug was dependent on immunopathogenesis, i.e., for catarrhal rhinosinusitis and deficiency of cellular immunity, we administered IFN-ES-lipint; in cases of purulent rhinosinusitis, Likopid was applied. The patients treated with immunomodulatory drugs showed improvement of immune indexes by the 7th day of treatment, along with return of substance P levels to control values typical to healthy persons. Among patients with low substance P levels and immune deficiency (without immunomodulatory treatment), the immune parameters and substance P levels did not exhibit any sufficient changes over time.Low contents of substance P (SP ≤ 100 pg /ml) in blood serum in pain-free patients with latent rhinosinusitis are indicative of immune deficiency and may serve as an indication for immune modulation therapy. Individual selection of the pathogenetically proven schedule therapy, when treating patients with latent (painless) rhinosinusitis may result into effective prevention of severe inflammation, normalization of immune response, prevention of a protracted disease course, and appropriate complications, as well as shortening of treatment terms to 8-10 days
format	article
author	I. V. Stagnieva A. S. Simbirtsev
author_facet	I. V. Stagnieva A. S. Simbirtsev
author_sort	I. V. Stagnieva
title	IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS
title_short	IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS
title_full	IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS
title_fullStr	IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS
title_full_unstemmed	IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS
title_sort	immunotherapy efficiency in rhinosinusitis patients
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/6b159a9a5ef24e3ea2d6337ec6d1b52b
work_keys_str_mv	AT ivstagnieva immunotherapyefficiencyinrhinosinusitispatients AT assimbirtsev immunotherapyefficiencyinrhinosinusitispatients
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IMMUNOTHERAPY EFFICIENCY IN RHINOSINUSITIS PATIENTS

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