Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease

Background: Cysteine-rich 61 (CYR61) and inflammation was upregulated in the lungs of patients with chronic obstructive pulmonary disease (COPD). However, the association between CYR61 and inflammation was unclear in COPD patients. This study aimed to analyze the association of serum CYR61 with pulm...

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Autores principales:	Zhu-Xia Tan, Lin Fu, Wen-Jing Wang, Ping Zhan, Hui Zhao, Hua Wang, De-Xiang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CYR61 COPD NF-κB lung function inflammatory cytokines Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b1959ee7c144cacb16365d129e79896
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spelling	oai:doaj.org-article:6b1959ee7c144cacb16365d129e798962021-12-01T15:35:40ZSerum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease2296-858X10.3389/fmed.2021.781596https://doaj.org/article/6b1959ee7c144cacb16365d129e798962021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.781596/fullhttps://doaj.org/toc/2296-858XBackground: Cysteine-rich 61 (CYR61) and inflammation was upregulated in the lungs of patients with chronic obstructive pulmonary disease (COPD). However, the association between CYR61 and inflammation was unclear in COPD patients. This study aimed to analyze the association of serum CYR61 with pulmonary inflammation and lung function indexes in COPD patients.Methods: One hundred and fifty COPD patients and 150 control subjects were enrolled. Serum and pulmonary CYR61 was detected. Lung function indexes were evaluated in COPD patients.Results: Serum CYR61 level was elevated and pulmonary CYR61 expression was upregulated in COPD patients. An increased CYR61 was associated with decreased pulmonary function indexes in COPD patients. Further analyses showed that nuclear factor-kappa B (NF-κB) p65-positive nuclei was elevated in the lungs of COPD patients with high level of CYR61. Accordingly, serum monocyte chemotactic protein (MCP)-1 and tumor necrosis factor α (TNF-α), two downstream inflammatory cytokines of NF-κB pathway, were increased in parallel with CYR61, among which serum MCP-1 and TNF-α were the highest in COPD patients with high level of CYR61. Moreover, a positive correlation, determined by multivariate regression that excluded the influence of age, gender and smoking, was observed between serum CYR61 and inflammatory cytokines in COPD patients.Conclusion: These results provide evidence that an increased CYR61 is associated with pulmonary inflammation and COPD progression. Inflammatory cytokines may be the mediators between CYR61 elevation and COPD progression.Zhu-Xia TanZhu-Xia TanLin FuWen-Jing WangPing ZhanHui ZhaoHua WangDe-Xiang XuFrontiers Media S.A.articleCYR61COPDNF-κBlung functioninflammatory cytokinesMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CYR61 COPD NF-κB lung function inflammatory cytokines Medicine (General) R5-920
spellingShingle	CYR61 COPD NF-κB lung function inflammatory cytokines Medicine (General) R5-920 Zhu-Xia Tan Zhu-Xia Tan Lin Fu Wen-Jing Wang Ping Zhan Hui Zhao Hua Wang De-Xiang Xu Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
description	Background: Cysteine-rich 61 (CYR61) and inflammation was upregulated in the lungs of patients with chronic obstructive pulmonary disease (COPD). However, the association between CYR61 and inflammation was unclear in COPD patients. This study aimed to analyze the association of serum CYR61 with pulmonary inflammation and lung function indexes in COPD patients.Methods: One hundred and fifty COPD patients and 150 control subjects were enrolled. Serum and pulmonary CYR61 was detected. Lung function indexes were evaluated in COPD patients.Results: Serum CYR61 level was elevated and pulmonary CYR61 expression was upregulated in COPD patients. An increased CYR61 was associated with decreased pulmonary function indexes in COPD patients. Further analyses showed that nuclear factor-kappa B (NF-κB) p65-positive nuclei was elevated in the lungs of COPD patients with high level of CYR61. Accordingly, serum monocyte chemotactic protein (MCP)-1 and tumor necrosis factor α (TNF-α), two downstream inflammatory cytokines of NF-κB pathway, were increased in parallel with CYR61, among which serum MCP-1 and TNF-α were the highest in COPD patients with high level of CYR61. Moreover, a positive correlation, determined by multivariate regression that excluded the influence of age, gender and smoking, was observed between serum CYR61 and inflammatory cytokines in COPD patients.Conclusion: These results provide evidence that an increased CYR61 is associated with pulmonary inflammation and COPD progression. Inflammatory cytokines may be the mediators between CYR61 elevation and COPD progression.
format	article
author	Zhu-Xia Tan Zhu-Xia Tan Lin Fu Wen-Jing Wang Ping Zhan Hui Zhao Hua Wang De-Xiang Xu
author_facet	Zhu-Xia Tan Zhu-Xia Tan Lin Fu Wen-Jing Wang Ping Zhan Hui Zhao Hua Wang De-Xiang Xu
author_sort	Zhu-Xia Tan
title	Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
title_short	Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
title_full	Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
title_fullStr	Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease
title_sort	serum cyr61 is associated with airway inflammation and is a potential biomarker for severity in chronic obstructive pulmonary disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6b1959ee7c144cacb16365d129e79896
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Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease

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