Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand

A new Schiff base ligand, 2-((E)-((4-(((E)-benzylidene)amino)phenyl)imino)methyl)-naphthalene-1-ol, was prepared by the reflux condensation of p-phenylenediamine with 2-hydroxy-1-naphthaldehyde and benzaldehyde. Metal complexes were prepared by reacting the ligand with metal salts: VCl3, CrCl3·6H2O,...

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Autores principales:	Thamer A. Alorini, Ahmed N. Al-Hakimi, S. El-Sayed Saeed, Ebtesam Hassan Lutf Alhamzi, Abuzar E.A.E. Albadri
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Schiff base complex Antibacterial activity Antifungal activity Anticancer activity Nanoparticle Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6b19c852f35146ed90d6c35454fad604
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spelling	oai:doaj.org-article:6b19c852f35146ed90d6c35454fad6042021-11-26T04:26:12ZSynthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand1878-535210.1016/j.arabjc.2021.103559https://doaj.org/article/6b19c852f35146ed90d6c35454fad6042022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005748https://doaj.org/toc/1878-5352A new Schiff base ligand, 2-((E)-((4-(((E)-benzylidene)amino)phenyl)imino)methyl)-naphthalene-1-ol, was prepared by the reflux condensation of p-phenylenediamine with 2-hydroxy-1-naphthaldehyde and benzaldehyde. Metal complexes were prepared by reacting the ligand with metal salts: VCl3, CrCl3·6H2O, MnCl2·3H2O, FeCl3·6H2O, CoCl3·6H2O, NiCl2·6H2O, CuCl2·2H2O, and ZnCl2. The ligand and its metallic complexes were characterized by various techniques such as elemental analysis, AAS, NMR, IR, UV–Vis, TGA, DTA, XRD and TEM. The data confirmed that the ligand coordinated with the metal ions in a bidentate nature, bonding through its azomethine nitrogen atom and phenolic oxygen atom; this gave an octahedral geometry. The XRD patterns of the complexes indicated that they were of various structures: the Mn(II), Co(III), and Cu(II) complexes were triclinic, the ligand and Ni(II) complex were orthorhombic, the V(III) and Zn(II) complexes were hexagonal, the Cu(II) complex was monoclinic, and the Fe(II) complex was cubic. TEM analysis confirmed that the complexes were nanoscale in nature. The antibacterial and antifungal activities of the ligand and its complexes against Salmonella enterica serovar typhi and Candida albicans were investigated by the hole plate diffusion method. It was observed that the Co(II) and Zn(II) complexes had intermediate antibacterial activities, while the V(III) complex had the highest activity against C. albicans fungi. The in vitro anticancer activities of the ligand and its metal complexes were tested towards PC-3, SKOV3, and HeLa tumour cell lines, where they exhibited higher antitumour activities against these selected human cell lines than clinically used drugs such as cisplatin, estramustine, and etoposide.Thamer A. AloriniAhmed N. Al-HakimiS. El-Sayed SaeedEbtesam Hassan Lutf AlhamziAbuzar E.A.E. AlbadriElsevierarticleSchiff base complexAntibacterial activityAntifungal activityAnticancer activityNanoparticleChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 2, Pp 103559- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schiff base complex Antibacterial activity Antifungal activity Anticancer activity Nanoparticle Chemistry QD1-999
spellingShingle	Schiff base complex Antibacterial activity Antifungal activity Anticancer activity Nanoparticle Chemistry QD1-999 Thamer A. Alorini Ahmed N. Al-Hakimi S. El-Sayed Saeed Ebtesam Hassan Lutf Alhamzi Abuzar E.A.E. Albadri Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand
description	A new Schiff base ligand, 2-((E)-((4-(((E)-benzylidene)amino)phenyl)imino)methyl)-naphthalene-1-ol, was prepared by the reflux condensation of p-phenylenediamine with 2-hydroxy-1-naphthaldehyde and benzaldehyde. Metal complexes were prepared by reacting the ligand with metal salts: VCl3, CrCl3·6H2O, MnCl2·3H2O, FeCl3·6H2O, CoCl3·6H2O, NiCl2·6H2O, CuCl2·2H2O, and ZnCl2. The ligand and its metallic complexes were characterized by various techniques such as elemental analysis, AAS, NMR, IR, UV–Vis, TGA, DTA, XRD and TEM. The data confirmed that the ligand coordinated with the metal ions in a bidentate nature, bonding through its azomethine nitrogen atom and phenolic oxygen atom; this gave an octahedral geometry. The XRD patterns of the complexes indicated that they were of various structures: the Mn(II), Co(III), and Cu(II) complexes were triclinic, the ligand and Ni(II) complex were orthorhombic, the V(III) and Zn(II) complexes were hexagonal, the Cu(II) complex was monoclinic, and the Fe(II) complex was cubic. TEM analysis confirmed that the complexes were nanoscale in nature. The antibacterial and antifungal activities of the ligand and its complexes against Salmonella enterica serovar typhi and Candida albicans were investigated by the hole plate diffusion method. It was observed that the Co(II) and Zn(II) complexes had intermediate antibacterial activities, while the V(III) complex had the highest activity against C. albicans fungi. The in vitro anticancer activities of the ligand and its metal complexes were tested towards PC-3, SKOV3, and HeLa tumour cell lines, where they exhibited higher antitumour activities against these selected human cell lines than clinically used drugs such as cisplatin, estramustine, and etoposide.
format	article
author	Thamer A. Alorini Ahmed N. Al-Hakimi S. El-Sayed Saeed Ebtesam Hassan Lutf Alhamzi Abuzar E.A.E. Albadri
author_facet	Thamer A. Alorini Ahmed N. Al-Hakimi S. El-Sayed Saeed Ebtesam Hassan Lutf Alhamzi Abuzar E.A.E. Albadri
author_sort	Thamer A. Alorini
title	Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand
title_short	Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand
title_full	Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand
title_fullStr	Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand
title_full_unstemmed	Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand
title_sort	synthesis, characterization, and anticancer activity of some metal complexes with a new schiff base ligand
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/6b19c852f35146ed90d6c35454fad604
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Synthesis, characterization, and anticancer activity of some metal complexes with a new Schiff base ligand

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