Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor

Abstract Gastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rati...

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Autores principales:	C. J. Martin, F. J. Veldman, D. Labadarios, Z. Ebrahim, E. Muller, S. M. Kassier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b1ac5ecc1c346aa856f600dd4bd2457
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spelling	oai:doaj.org-article:6b1ac5ecc1c346aa856f600dd4bd24572021-12-02T17:40:45ZGastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor10.1038/s41598-021-92016-22045-2322https://doaj.org/article/6b1ac5ecc1c346aa856f600dd4bd24572021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92016-2https://doaj.org/toc/2045-2322Abstract Gastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rating scale (GSRS) was completed by 76 participants at baseline and at 6 months. GIS frequency was defined as having at least one symptom (GSRS > 1). Severity was indicated by the GSRS score. Transplant candidates: GIS frequency was 88.9% and 86.3% at baseline and 6 months respectively. Indigestion was the most frequent (79.6% and 66.7% at baseline and 6 months), and severe GIS (GSRS 2.3). Women reported global mean (p = 0.030) severity significantly more than men. Transplant recipients: GIS frequency was 95.2% and 76.2% at baseline and 6 months respectively. At both assessment points, indigestion occurred most frequently (85.7% and 61.9% respectively). Highest GSRS was reported for indigestion at baseline (2.33) and at 6 months (1.33). Waist circumference (WC) was positively associated with the severity of constipation GSRS. GIS are common in both groups, especially indigestions. WC in transplant recipients should be monitored.C. J. MartinF. J. VeldmanD. LabadariosZ. EbrahimE. MullerS. M. KassierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q C. J. Martin F. J. Veldman D. Labadarios Z. Ebrahim E. Muller S. M. Kassier Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
description	Abstract Gastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rating scale (GSRS) was completed by 76 participants at baseline and at 6 months. GIS frequency was defined as having at least one symptom (GSRS > 1). Severity was indicated by the GSRS score. Transplant candidates: GIS frequency was 88.9% and 86.3% at baseline and 6 months respectively. Indigestion was the most frequent (79.6% and 66.7% at baseline and 6 months), and severe GIS (GSRS 2.3). Women reported global mean (p = 0.030) severity significantly more than men. Transplant recipients: GIS frequency was 95.2% and 76.2% at baseline and 6 months respectively. At both assessment points, indigestion occurred most frequently (85.7% and 61.9% respectively). Highest GSRS was reported for indigestion at baseline (2.33) and at 6 months (1.33). Waist circumference (WC) was positively associated with the severity of constipation GSRS. GIS are common in both groups, especially indigestions. WC in transplant recipients should be monitored.
format	article
author	C. J. Martin F. J. Veldman D. Labadarios Z. Ebrahim E. Muller S. M. Kassier
author_facet	C. J. Martin F. J. Veldman D. Labadarios Z. Ebrahim E. Muller S. M. Kassier
author_sort	C. J. Martin
title	Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
title_short	Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
title_full	Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
title_fullStr	Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
title_full_unstemmed	Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
title_sort	gastrointestinal symptoms in hiv-positive kidney transplant candidates and recipients from an hiv-positive donor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b1ac5ecc1c346aa856f600dd4bd2457
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Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor

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