NLK is a novel therapeutic target for PTEN deficient tumour cells.

NLK is a novel therapeutic target for PTEN deficient tumour cells.

PTEN (Phosphatase and tensin homolog) is a tumour suppressor gene commonly defective in human cancer, and is thus a potentially important therapeutic target. Targeting tumour suppressor loss-of-function is possible by exploiting the genetic concept of synthetic lethality (SL). By combining the use o...

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Autores principales: Ana M Mendes-Pereira, Christopher J Lord, Alan Ashworth
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/6b1c5800cf294b4893d83204f84bf90b
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