Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation

Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation

Abstract Hypertension and aneurysm are frequently associated with autosomal dominant polycystic kidney disease (ADPKD) caused by polycystin-1 (PC1) mutations, which is closely related to endothelial dysfunction. PC1 is an atypical G-protein-coupled receptor that activates G-proteins by self-cleavage...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Misun Kwak, Chansik Hong, Jongyun Myeong, Eunice Yon June Park, Ju-Hong Jeon, Insuk So
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6b1dac94af454f40b779ad80c02bde32
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares