Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging

Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming l...

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Autores principales: Kyung Lock Kim, Gihyun Sung, Jaehwan Sim, James Murray, Meng Li, Ara Lee, Annadka Shrinidhi, Kyeng Min Park, Kimoon Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6b1df780ac2341cc9ff12fa02ca90191
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Sumario:Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming limitations of protein-based platforms.