Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging

Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming l...

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Autores principales:	Kyung Lock Kim, Gihyun Sung, Jaehwan Sim, James Murray, Meng Li, Ara Lee, Annadka Shrinidhi, Kyeng Min Park, Kimoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b1df780ac2341cc9ff12fa02ca90191
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spelling	oai:doaj.org-article:6b1df780ac2341cc9ff12fa02ca901912021-12-02T16:49:21ZSupramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging10.1038/s41467-018-04161-42041-1723https://doaj.org/article/6b1df780ac2341cc9ff12fa02ca901912018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04161-4https://doaj.org/toc/2041-1723Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming limitations of protein-based platforms.Kyung Lock KimGihyun SungJaehwan SimJames MurrayMeng LiAra LeeAnnadka ShrinidhiKyeng Min ParkKimoon KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyung Lock Kim Gihyun Sung Jaehwan Sim James Murray Meng Li Ara Lee Annadka Shrinidhi Kyeng Min Park Kimoon Kim Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
description	Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming limitations of protein-based platforms.
format	article
author	Kyung Lock Kim Gihyun Sung Jaehwan Sim James Murray Meng Li Ara Lee Annadka Shrinidhi Kyeng Min Park Kimoon Kim
author_facet	Kyung Lock Kim Gihyun Sung Jaehwan Sim James Murray Meng Li Ara Lee Annadka Shrinidhi Kyeng Min Park Kimoon Kim
author_sort	Kyung Lock Kim
title	Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
title_short	Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
title_full	Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
title_fullStr	Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
title_full_unstemmed	Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
title_sort	supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6b1df780ac2341cc9ff12fa02ca90191
work_keys_str_mv	AT kyunglockkim supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT gihyunsung supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT jaehwansim supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT jamesmurray supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT mengli supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT aralee supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT annadkashrinidhi supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT kyengminpark supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging AT kimoonkim supramolecularlatchingsystembasedonultrastablesyntheticbindingpairsasversatiletoolsforproteinimaging
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Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging

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