Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy

Introduction. The microbial biofilm-forming ability is one of the major aspects of the emerging issue of antibiotic resistance, which makes them tolerant to antibiotics and host defense systems and other external stresses, thus contributing to persistent chronic infections. A series of relevant stud...

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Autores principales:	Nina VRYNCHANU, Yurii KOROTKIJ, Nataliia HRYNCHUK, Irina BOIKO, Elena SMERTENKO, Larisa BONDARENKO
Formato:	article
Lenguaje:	EN FR RO RU
Publicado:	Asociatia de Biosiguranta si Biosecuritate 2021
Materias:	aminopropanol derivatives antimicrobial activity bacteria biofilm Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b1f89b1e6ec4a6b8455bc53892043f7
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spelling	oai:doaj.org-article:6b1f89b1e6ec4a6b8455bc53892043f72021-12-02T17:40:13ZAntimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy10.38045/ohrm.2021.3.042887-34582587-3466https://doaj.org/article/6b1f89b1e6ec4a6b8455bc53892043f72021-06-01T00:00:00Zhttps://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/115/94https://doaj.org/toc/2887-3458https://doaj.org/toc/2587-3466Introduction. The microbial biofilm-forming ability is one of the major aspects of the emerging issue of antibiotic resistance, which makes them tolerant to antibiotics and host defense systems and other external stresses, thus contributing to persistent chronic infections. A series of relevant studies confirmed the high efficiency of aminopropanol derivatives as potential antibacterial and antifungal agents. This present study was aimed to evaluate the antimicrobial activity of new 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives on the planktonic bacterial/fungal cells and biofilms. Material and methods. The minimum inhibitory concentrations (MIC) of the new compounds were determined by a standard method, along with their effects on biofilms estimated via the gentian violet adsorption-desorption assay. Results. The КVM-219 compound showed the most pronounced effect on planktonic bacterial and fungal cells. The MIC values ranged between 0.78 μg/mL to 12.5 μg/mL, depending on the microbial strain. The KVM-316 compound exhibited the strongest inhibitory effect on biofilms, thus preventing their formation by S. aureus (96.1%), E. coli (57.2%), and P. aeruginosa (96.1%). Conclusions. The 15 newly synthesized 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives revealed marked antibacterial and antifungal effects on planktonic microorganisms. Most of these compounds showed a strain-specific inhibition of biofilm formation by at least 50% for S. aureus 222, E. coli 311, P. aeruginosa 449 and C. glabrata 404 strains.Nina VRYNCHANUYurii KOROTKIJNataliia HRYNCHUKIrina BOIKOElena SMERTENKOLarisa BONDARENKOAsociatia de Biosiguranta si Biosecuritatearticleaminopropanol derivativesantimicrobial activitybacteriabiofilmMedicineRScienceQENFRRORUOne Health & Risk Management, Vol 2, Iss 3, Pp 27-33 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR RO RU
topic	aminopropanol derivatives antimicrobial activity bacteria biofilm Medicine R Science Q
spellingShingle	aminopropanol derivatives antimicrobial activity bacteria biofilm Medicine R Science Q Nina VRYNCHANU Yurii KOROTKIJ Nataliia HRYNCHUK Irina BOIKO Elena SMERTENKO Larisa BONDARENKO Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
description	Introduction. The microbial biofilm-forming ability is one of the major aspects of the emerging issue of antibiotic resistance, which makes them tolerant to antibiotics and host defense systems and other external stresses, thus contributing to persistent chronic infections. A series of relevant studies confirmed the high efficiency of aminopropanol derivatives as potential antibacterial and antifungal agents. This present study was aimed to evaluate the antimicrobial activity of new 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives on the planktonic bacterial/fungal cells and biofilms. Material and methods. The minimum inhibitory concentrations (MIC) of the new compounds were determined by a standard method, along with their effects on biofilms estimated via the gentian violet adsorption-desorption assay. Results. The КVM-219 compound showed the most pronounced effect on planktonic bacterial and fungal cells. The MIC values ranged between 0.78 μg/mL to 12.5 μg/mL, depending on the microbial strain. The KVM-316 compound exhibited the strongest inhibitory effect on biofilms, thus preventing their formation by S. aureus (96.1%), E. coli (57.2%), and P. aeruginosa (96.1%). Conclusions. The 15 newly synthesized 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives revealed marked antibacterial and antifungal effects on planktonic microorganisms. Most of these compounds showed a strain-specific inhibition of biofilm formation by at least 50% for S. aureus 222, E. coli 311, P. aeruginosa 449 and C. glabrata 404 strains.
format	article
author	Nina VRYNCHANU Yurii KOROTKIJ Nataliia HRYNCHUK Irina BOIKO Elena SMERTENKO Larisa BONDARENKO
author_facet	Nina VRYNCHANU Yurii KOROTKIJ Nataliia HRYNCHUK Irina BOIKO Elena SMERTENKO Larisa BONDARENKO
author_sort	Nina VRYNCHANU
title	Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
title_short	Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
title_full	Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
title_fullStr	Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
title_full_unstemmed	Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
title_sort	antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy
publisher	Asociatia de Biosiguranta si Biosecuritate
publishDate	2021
url	https://doaj.org/article/6b1f89b1e6ec4a6b8455bc53892043f7
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Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy

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