Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

Inverse electron-demand cycloadditions in palladium catalysis are inherently limited by the linear selectivity in the allylic substitution step. To overcome this issue, the authors report a synergetic iridium (branched-selective) and amine catalysis in [4+2] cycloadditions of vinyl aminoalcohols wit...

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Autores principales: Mao-Mao Zhang, Ya-Ni Wang, Bao-Cheng Wang, Xiao-Wang Chen, Liang-Qiu Lu, Wen-Jing Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6b1fe359aea049698ea081237c61b43d
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Sumario:Inverse electron-demand cycloadditions in palladium catalysis are inherently limited by the linear selectivity in the allylic substitution step. To overcome this issue, the authors report a synergetic iridium (branched-selective) and amine catalysis in [4+2] cycloadditions of vinyl aminoalcohols with carbonyls.