Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella

So far no enzymatic activity has been attributed to flagellin, the major component of bacterial flagella. Here the authors use bioinformatic analysis and identify a metallopeptidase insertion in flagellins from 74 bacterial species and show that recombinant flagellin and flagellar filaments have pro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ulrich Eckhard, Hina Bandukwala, Michael J. Mansfield, Giada Marino, Jiujun Cheng, Iain Wallace, Todd Holyoak, Trevor C. Charles, John Austin, Christopher M. Overall, Andrew C. Doxey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b22cc74b7244dd6af78e171528c4506
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6b22cc74b7244dd6af78e171528c4506
record_format	dspace
spelling	oai:doaj.org-article:6b22cc74b7244dd6af78e171528c45062021-12-02T14:42:07ZDiscovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella10.1038/s41467-017-00599-02041-1723https://doaj.org/article/6b22cc74b7244dd6af78e171528c45062017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00599-0https://doaj.org/toc/2041-1723So far no enzymatic activity has been attributed to flagellin, the major component of bacterial flagella. Here the authors use bioinformatic analysis and identify a metallopeptidase insertion in flagellins from 74 bacterial species and show that recombinant flagellin and flagellar filaments have proteolytic activity.Ulrich EckhardHina BandukwalaMichael J. MansfieldGiada MarinoJiujun ChengIain WallaceTodd HolyoakTrevor C. CharlesJohn AustinChristopher M. OverallAndrew C. DoxeyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ulrich Eckhard Hina Bandukwala Michael J. Mansfield Giada Marino Jiujun Cheng Iain Wallace Todd Holyoak Trevor C. Charles John Austin Christopher M. Overall Andrew C. Doxey Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
description	So far no enzymatic activity has been attributed to flagellin, the major component of bacterial flagella. Here the authors use bioinformatic analysis and identify a metallopeptidase insertion in flagellins from 74 bacterial species and show that recombinant flagellin and flagellar filaments have proteolytic activity.
format	article
author	Ulrich Eckhard Hina Bandukwala Michael J. Mansfield Giada Marino Jiujun Cheng Iain Wallace Todd Holyoak Trevor C. Charles John Austin Christopher M. Overall Andrew C. Doxey
author_facet	Ulrich Eckhard Hina Bandukwala Michael J. Mansfield Giada Marino Jiujun Cheng Iain Wallace Todd Holyoak Trevor C. Charles John Austin Christopher M. Overall Andrew C. Doxey
author_sort	Ulrich Eckhard
title	Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
title_short	Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
title_full	Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
title_fullStr	Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
title_full_unstemmed	Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
title_sort	discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6b22cc74b7244dd6af78e171528c4506
work_keys_str_mv	AT ulricheckhard discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT hinabandukwala discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT michaeljmansfield discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT giadamarino discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT jiujuncheng discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT iainwallace discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT toddholyoak discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT trevorccharles discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT johnaustin discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT christophermoverall discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella AT andrewcdoxey discoveryofaproteolyticflagellinfamilyindiversebacterialphylathatassemblesenzymaticallyactiveflagella
_version_	1718389813138161664

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella

Ejemplares similares