Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus
ABSTRACT Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is one of the most medically important tick-borne pathogens of the Old World. Despite decades of active research, attempts to develop of a live attenuated virus (LAV) vaccine against TBEV with acceptable safety and immu...
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Auteurs principaux: | Konstantin A. Tsetsarkin, Olga A. Maximova, Guangping Liu, Heather Kenney, Natalya L. Teterina, Alexander G. Pletnev |
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Format: | article |
Langue: | EN |
Publié: |
American Society for Microbiology
2019
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Accès en ligne: | https://doaj.org/article/6b22eb81158b4f61bc66018557d6a62c |
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