Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus

Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus

ABSTRACT Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is one of the most medically important tick-borne pathogens of the Old World. Despite decades of active research, attempts to develop of a live attenuated virus (LAV) vaccine against TBEV with acceptable safety and immu...

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Autores principales: Konstantin A. Tsetsarkin, Olga A. Maximova, Guangping Liu, Heather Kenney, Natalya L. Teterina, Alexander G. Pletnev
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Langat virus
tick-borne encephalitis virus
chimeric virus
live attenuated virus vaccine
microRNA
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/6b22eb81158b4f61bc66018557d6a62c
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