Long-term effect of early-life stress from earthquake exposure on working memory in adulthood
Na Li,1-3* Yumei Wang,1-3* Xiaochuan Zhao,1-3 Yuanyuan Gao,1-3 Mei Song,1-3 Lulu Yu,1-3 Lan Wang,1-3 Ning Li,1-3 Qianqian Chen,1-3 Yunpeng Li,1-3 Jiajia Cai,1-3 Xueyi Wang1-31Department of Psychiatry, The First Hospital...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2015
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6b23bae814a340c2b60f4ad273db9b6c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6b23bae814a340c2b60f4ad273db9b6c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6b23bae814a340c2b60f4ad273db9b6c2021-12-02T01:51:34ZLong-term effect of early-life stress from earthquake exposure on working memory in adulthood1178-2021https://doaj.org/article/6b23bae814a340c2b60f4ad273db9b6c2015-11-01T00:00:00Zhttps://www.dovepress.com/long-term-effect-of-early-life-stress-from-earthquake-exposure-on-work-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Na Li,1-3* Yumei Wang,1-3* Xiaochuan Zhao,1-3 Yuanyuan Gao,1-3 Mei Song,1-3 Lulu Yu,1-3 Lan Wang,1-3 Ning Li,1-3 Qianqian Chen,1-3 Yunpeng Li,1-3 Jiajia Cai,1-3 Xueyi Wang1-31Department of Psychiatry, The First Hospital of Hebei Medical University, 2Mental Health Institute of Hebei Medical University, 3Brain Ageing and Cognitive Neuroscience Laboratory, Hebei, People’s Republic of China *These authors contributed equally to this work Objective: The present study aimed to investigate the long-term effect of 1976 Tangshan earthquake exposure in early life on performance of working memory in adulthood.Methods: A total of 907 study subjects born and raised in Tangshan were enrolled in this study. They were divided into three groups according to the dates of birth: infant exposure (3–12 months, n=274), prenatal exposure (n=269), and no exposure (born at least 1 year after the earthquake, n=364). The prenatal group was further divided into first, second, and third trimester subgroups based on the timing of exposure during pregnancy. Hopkins Verbal Learning Test-Revised and Brief Visuospatial Memory Test-Revised (BVMT-R) were used to measure the performance of working memory. Unconditional logistic regression analysis was used to analyze the influential factors for impaired working memory.Results: The Hopkins Verbal Learning Test-Revised scores did not show significant difference across the three groups. Compared with no exposure group, the BVMT-R scores were slightly lower in the prenatal exposure group and markedly decreased in the infant exposure group. When the BVMT-R scores were analyzed in three subgroups, the results showed that the subjects whose mothers were exposed to earthquake in the second and third trimesters of pregnancy had significantly lower BVMT-R scores compared with those in the first trimester. Education level and early-life earthquake exposure were identified as independent risk factors for reduced performance of visuospatial memory indicated by lower BVMT-R scores.Conclusion: Infant exposure to earthquake-related stress impairs visuospatial memory in adulthood. Fetuses in the middle and late stages of development are more vulnerable to stress-induced damage that consequently results in impaired visuospatial memory. Education and early-life trauma can also influence the performance of working memory in adulthood. Keywords: Tangshan earthquake, early life stress, working memory, chronic effectLi NWang YZhao XGao YSong MYu LWang LLi NChen QLi YCai JWang XDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2959-2965 (2015) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li N Wang Y Zhao X Gao Y Song M Yu L Wang L Li N Chen Q Li Y Cai J Wang X Long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| description |
Na Li,1-3* Yumei Wang,1-3* Xiaochuan Zhao,1-3 Yuanyuan Gao,1-3 Mei Song,1-3 Lulu Yu,1-3 Lan Wang,1-3 Ning Li,1-3 Qianqian Chen,1-3 Yunpeng Li,1-3 Jiajia Cai,1-3 Xueyi Wang1-31Department of Psychiatry, The First Hospital of Hebei Medical University, 2Mental Health Institute of Hebei Medical University, 3Brain Ageing and Cognitive Neuroscience Laboratory, Hebei, People’s Republic of China *These authors contributed equally to this work Objective: The present study aimed to investigate the long-term effect of 1976 Tangshan earthquake exposure in early life on performance of working memory in adulthood.Methods: A total of 907 study subjects born and raised in Tangshan were enrolled in this study. They were divided into three groups according to the dates of birth: infant exposure (3–12 months, n=274), prenatal exposure (n=269), and no exposure (born at least 1 year after the earthquake, n=364). The prenatal group was further divided into first, second, and third trimester subgroups based on the timing of exposure during pregnancy. Hopkins Verbal Learning Test-Revised and Brief Visuospatial Memory Test-Revised (BVMT-R) were used to measure the performance of working memory. Unconditional logistic regression analysis was used to analyze the influential factors for impaired working memory.Results: The Hopkins Verbal Learning Test-Revised scores did not show significant difference across the three groups. Compared with no exposure group, the BVMT-R scores were slightly lower in the prenatal exposure group and markedly decreased in the infant exposure group. When the BVMT-R scores were analyzed in three subgroups, the results showed that the subjects whose mothers were exposed to earthquake in the second and third trimesters of pregnancy had significantly lower BVMT-R scores compared with those in the first trimester. Education level and early-life earthquake exposure were identified as independent risk factors for reduced performance of visuospatial memory indicated by lower BVMT-R scores.Conclusion: Infant exposure to earthquake-related stress impairs visuospatial memory in adulthood. Fetuses in the middle and late stages of development are more vulnerable to stress-induced damage that consequently results in impaired visuospatial memory. Education and early-life trauma can also influence the performance of working memory in adulthood. Keywords: Tangshan earthquake, early life stress, working memory, chronic effect |
| format |
article |
| author |
Li N Wang Y Zhao X Gao Y Song M Yu L Wang L Li N Chen Q Li Y Cai J Wang X |
| author_facet |
Li N Wang Y Zhao X Gao Y Song M Yu L Wang L Li N Chen Q Li Y Cai J Wang X |
| author_sort |
Li N |
| title |
Long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| title_short |
Long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| title_full |
Long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| title_fullStr |
Long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| title_full_unstemmed |
Long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| title_sort |
long-term effect of early-life stress from earthquake exposure on working memory in adulthood |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/6b23bae814a340c2b60f4ad273db9b6c |
| work_keys_str_mv |
AT lin longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT wangy longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT zhaox longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT gaoy longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT songm longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT yul longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT wangl longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT lin longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT chenq longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT liy longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT caij longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood AT wangx longtermeffectofearlylifestressfromearthquakeexposureonworkingmemoryinadulthood |
| _version_ |
1718402843873902592 |