A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis

Yue-Rong Zhang,1 Hui Wang,2 Ning Zhou,2 Yao-Di Zhang,1,2 Yan Lin,1,2 Li-Yang Wu,1,2 Shi-Fang Wei,2 Yan-Yun Ma,2,3 Chun-Xia Wang3 1Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Infectious Diseases, The F...

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Autores principales:	Zhang YR, Wang H, Zhou N, Zhang YD, Lin Y, Wu LY, Wei SF, Ma YY, Wang CX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	liver cirrhosis decompensated period multidisciplinary team mode traditional treatment retrospective study Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6b2666fa48d840a29321ab78f88b00e9
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spelling	oai:doaj.org-article:6b2666fa48d840a29321ab78f88b00e92021-12-02T16:52:24ZA Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis1178-7031https://doaj.org/article/6b2666fa48d840a29321ab78f88b00e92021-10-01T00:00:00Zhttps://www.dovepress.com/a-multidisciplinary-team-approach-to-the-treatment-of-liver-cirrhosis-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Yue-Rong Zhang,1 Hui Wang,2 Ning Zhou,2 Yao-Di Zhang,1,2 Yan Lin,1,2 Li-Yang Wu,1,2 Shi-Fang Wei,2 Yan-Yun Ma,2,3 Chun-Xia Wang3 1Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Infectious Diseases, The First People’s Hospital of Lanzhou, Gansu, 730050, People’s Republic of China; 3Department of Laboratory, The First People’s Hospital of Lanzhou, Gansu, 730050, People’s Republic of ChinaCorrespondence: Yue-Rong ZhangDepartment of Gastroenterology, University-Town Hospital of Chongqing Medical University, No. 55 University Town Middle Road, Shapingba District, Chongqing, 401331, People’s Republic of ChinaTel/Fax +86 102365714142Email zhang_yue_rong@163.comObjective: To explore the feasibility of treating cirrhosis using a multidisciplinary team approach (MDT) and to pinpoint the key factors influencing its implementation.Methods: The data of 307 patients with decompensated cirrhosis were studied retrospectively. Patients who received more than two treatment measures were assigned to the MDT group (n=228), and patients who received symptomatic medical drug treatment only were assigned to the traditional treatment group (n=79). The follow-up period ranged from 4 to 10 years, and the average follow-up period was 5.7 years. The results of the biochemical tests for hepatitis B virus deoxyribonucleic acid, hepatitis C virus ribonucleic acid, and autoantibodies to liver disease were analyzed.Results: The differences in gender and Child–Pugh grade of liver function between the two groups were not statistically significant. The MDT group had obvious advantages over the traditional treatment group in occupational composition, etiology composition, 5-year survival rate and annual hospitalization times. The leading causes of death in the MDT group, in descending order, were liver cancer, infection, mesenteric thrombosis, and non-hepatic disease, and, in the medical treatment group, they were liver failure, gastrointestinal bleeding, infection, and liver cancer. There was a significant statistical difference between the two groups (p < 0.05). In the multidisciplinary treatment, etiological treatment was the most widely used treatment, accounting for 79.8%, followed by endoscopic treatment (33.3%), peritoneal drainage and ascites reinfusion (25%), splenectomy combined with devascularization (11.4%) and stem cell transplantation and liver transplantation (1.8%).Conclusion: An MDT can improve the efficacy and prognosis of patients with cirrhosis and improve patient compliance. After multi-disciplinary intervention, the mortality spectrum of long-term survival patients with cirrhosis changes, and the mortality rate of liver cancer and non-liver disease increases.Keywords: liver cirrhosis, decompensated period, multidisciplinary team mode, traditional treatment, retrospective studyZhang YRWang HZhou NZhang YDLin YWu LYWei SFMa YYWang CXDove Medical Pressarticleliver cirrhosisdecompensated periodmultidisciplinary team modetraditional treatmentretrospective studyPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5443-5450 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver cirrhosis decompensated period multidisciplinary team mode traditional treatment retrospective study Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	liver cirrhosis decompensated period multidisciplinary team mode traditional treatment retrospective study Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zhang YR Wang H Zhou N Zhang YD Lin Y Wu LY Wei SF Ma YY Wang CX A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
description	Yue-Rong Zhang,1 Hui Wang,2 Ning Zhou,2 Yao-Di Zhang,1,2 Yan Lin,1,2 Li-Yang Wu,1,2 Shi-Fang Wei,2 Yan-Yun Ma,2,3 Chun-Xia Wang3 1Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Infectious Diseases, The First People’s Hospital of Lanzhou, Gansu, 730050, People’s Republic of China; 3Department of Laboratory, The First People’s Hospital of Lanzhou, Gansu, 730050, People’s Republic of ChinaCorrespondence: Yue-Rong ZhangDepartment of Gastroenterology, University-Town Hospital of Chongqing Medical University, No. 55 University Town Middle Road, Shapingba District, Chongqing, 401331, People’s Republic of ChinaTel/Fax +86 102365714142Email zhang_yue_rong@163.comObjective: To explore the feasibility of treating cirrhosis using a multidisciplinary team approach (MDT) and to pinpoint the key factors influencing its implementation.Methods: The data of 307 patients with decompensated cirrhosis were studied retrospectively. Patients who received more than two treatment measures were assigned to the MDT group (n=228), and patients who received symptomatic medical drug treatment only were assigned to the traditional treatment group (n=79). The follow-up period ranged from 4 to 10 years, and the average follow-up period was 5.7 years. The results of the biochemical tests for hepatitis B virus deoxyribonucleic acid, hepatitis C virus ribonucleic acid, and autoantibodies to liver disease were analyzed.Results: The differences in gender and Child–Pugh grade of liver function between the two groups were not statistically significant. The MDT group had obvious advantages over the traditional treatment group in occupational composition, etiology composition, 5-year survival rate and annual hospitalization times. The leading causes of death in the MDT group, in descending order, were liver cancer, infection, mesenteric thrombosis, and non-hepatic disease, and, in the medical treatment group, they were liver failure, gastrointestinal bleeding, infection, and liver cancer. There was a significant statistical difference between the two groups (p < 0.05). In the multidisciplinary treatment, etiological treatment was the most widely used treatment, accounting for 79.8%, followed by endoscopic treatment (33.3%), peritoneal drainage and ascites reinfusion (25%), splenectomy combined with devascularization (11.4%) and stem cell transplantation and liver transplantation (1.8%).Conclusion: An MDT can improve the efficacy and prognosis of patients with cirrhosis and improve patient compliance. After multi-disciplinary intervention, the mortality spectrum of long-term survival patients with cirrhosis changes, and the mortality rate of liver cancer and non-liver disease increases.Keywords: liver cirrhosis, decompensated period, multidisciplinary team mode, traditional treatment, retrospective study
format	article
author	Zhang YR Wang H Zhou N Zhang YD Lin Y Wu LY Wei SF Ma YY Wang CX
author_facet	Zhang YR Wang H Zhou N Zhang YD Lin Y Wu LY Wei SF Ma YY Wang CX
author_sort	Zhang YR
title	A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
title_short	A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
title_full	A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
title_fullStr	A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
title_full_unstemmed	A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
title_sort	multidisciplinary team approach to the treatment of liver cirrhosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6b2666fa48d840a29321ab78f88b00e9
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A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis

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