TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

In pancreatic ductal adenocarcinoma, TGF-β/Activin induce epithelial-to-mesenchymal transition (EMT) and stemness. Here, the authors show that TGF-β induces pro-tumourigenic miR-100 and miR-125b, but blocks anti-tumourigenic let-7a maturation via LIN28B, regulating pathways to promote stemness, EMT...

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Autores principales:	Silvia Ottaviani, Justin Stebbing, Adam E. Frampton, Sladjana Zagorac, Jonathan Krell, Alexander de Giorgio, Sara M. Trabulo, Van T. M. Nguyen, Luca Magnani, Hugang Feng, Elisa Giovannetti, Niccola Funel, Thomas M. Gress, Long R. Jiao, Ylenia Lombardo, Nicholas R. Lemoine, Christopher Heeschen, Leandro Castellano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b26f0de8fb24a82b752ef7f07fc000b
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spelling	oai:doaj.org-article:6b26f0de8fb24a82b752ef7f07fc000b2021-12-02T15:34:48ZTGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression10.1038/s41467-018-03962-x2041-1723https://doaj.org/article/6b26f0de8fb24a82b752ef7f07fc000b2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03962-xhttps://doaj.org/toc/2041-1723In pancreatic ductal adenocarcinoma, TGF-β/Activin induce epithelial-to-mesenchymal transition (EMT) and stemness. Here, the authors show that TGF-β induces pro-tumourigenic miR-100 and miR-125b, but blocks anti-tumourigenic let-7a maturation via LIN28B, regulating pathways to promote stemness, EMT and tumourigenesis.Silvia OttavianiJustin StebbingAdam E. FramptonSladjana ZagoracJonathan KrellAlexander de GiorgioSara M. TrabuloVan T. M. NguyenLuca MagnaniHugang FengElisa GiovannettiNiccola FunelThomas M. GressLong R. JiaoYlenia LombardoNicholas R. LemoineChristopher HeeschenLeandro CastellanoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Ottaviani Justin Stebbing Adam E. Frampton Sladjana Zagorac Jonathan Krell Alexander de Giorgio Sara M. Trabulo Van T. M. Nguyen Luca Magnani Hugang Feng Elisa Giovannetti Niccola Funel Thomas M. Gress Long R. Jiao Ylenia Lombardo Nicholas R. Lemoine Christopher Heeschen Leandro Castellano TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
description	In pancreatic ductal adenocarcinoma, TGF-β/Activin induce epithelial-to-mesenchymal transition (EMT) and stemness. Here, the authors show that TGF-β induces pro-tumourigenic miR-100 and miR-125b, but blocks anti-tumourigenic let-7a maturation via LIN28B, regulating pathways to promote stemness, EMT and tumourigenesis.
format	article
author	Silvia Ottaviani Justin Stebbing Adam E. Frampton Sladjana Zagorac Jonathan Krell Alexander de Giorgio Sara M. Trabulo Van T. M. Nguyen Luca Magnani Hugang Feng Elisa Giovannetti Niccola Funel Thomas M. Gress Long R. Jiao Ylenia Lombardo Nicholas R. Lemoine Christopher Heeschen Leandro Castellano
author_facet	Silvia Ottaviani Justin Stebbing Adam E. Frampton Sladjana Zagorac Jonathan Krell Alexander de Giorgio Sara M. Trabulo Van T. M. Nguyen Luca Magnani Hugang Feng Elisa Giovannetti Niccola Funel Thomas M. Gress Long R. Jiao Ylenia Lombardo Nicholas R. Lemoine Christopher Heeschen Leandro Castellano
author_sort	Silvia Ottaviani
title	TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
title_short	TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
title_full	TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
title_fullStr	TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
title_full_unstemmed	TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
title_sort	tgf-β induces mir-100 and mir-125b but blocks let-7a through lin28b controlling pdac progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6b26f0de8fb24a82b752ef7f07fc000b
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TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

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