Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development

ABSTRACT Economic development is marked by dramatic increases in the incidence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for...

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Autores principales:	Keaton Stagaman, Tara J. Cepon-Robins, Melissa A. Liebert, Theresa E. Gildner, Samuel S. Urlacher, Felicia C. Madimenos, Karen Guillemin, J. Josh Snodgrass, Lawrence S. Sugiyama, Brendan J. M. Bohannan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	biological anthropology market integration microbial ecology microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6b2b0ac1ec0b4de394f43653e5650e18
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spelling	oai:doaj.org-article:6b2b0ac1ec0b4de394f43653e5650e182021-12-02T19:47:33ZMarket Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development10.1128/mSystems.00122-172379-5077https://doaj.org/article/6b2b0ac1ec0b4de394f43653e5650e182018-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00122-17https://doaj.org/toc/2379-5077ABSTRACT Economic development is marked by dramatic increases in the incidence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of speciﬁc market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and proﬁled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with signiﬁcantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items. IMPORTANCE Previous research has reported differences in the gut microbiome between populations residing in wealthy versus poorer countries, leading to the assertion that lifestyle changes associated with economic development promote changes in the gut microbiome that promote the proliferation of microbiome-associated diseases. However, a direct relationship between economic development and the gut microbiome has not previously been shown. We surveyed the gut microbiomes of a single indigenous population undergoing economic development and found signiﬁcant associations between features of the gut microbiome and lifestyle changes associated with economic development. These ﬁndings suggest that even the earliest stages of economic development can drive changes in the gut microbiome, which may provide a warning sign for the development of microbiome-associated diseases.Keaton StagamanTara J. Cepon-RobinsMelissa A. LiebertTheresa E. GildnerSamuel S. UrlacherFelicia C. MadimenosKaren GuilleminJ. Josh SnodgrassLawrence S. SugiyamaBrendan J. M. BohannanAmerican Society for Microbiologyarticlebiological anthropologymarket integrationmicrobial ecologymicrobiomeMicrobiologyQR1-502ENmSystems, Vol 3, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological anthropology market integration microbial ecology microbiome Microbiology QR1-502
spellingShingle	biological anthropology market integration microbial ecology microbiome Microbiology QR1-502 Keaton Stagaman Tara J. Cepon-Robins Melissa A. Liebert Theresa E. Gildner Samuel S. Urlacher Felicia C. Madimenos Karen Guillemin J. Josh Snodgrass Lawrence S. Sugiyama Brendan J. M. Bohannan Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development
description	ABSTRACT Economic development is marked by dramatic increases in the incidence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of speciﬁc market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and proﬁled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with signiﬁcantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items. IMPORTANCE Previous research has reported differences in the gut microbiome between populations residing in wealthy versus poorer countries, leading to the assertion that lifestyle changes associated with economic development promote changes in the gut microbiome that promote the proliferation of microbiome-associated diseases. However, a direct relationship between economic development and the gut microbiome has not previously been shown. We surveyed the gut microbiomes of a single indigenous population undergoing economic development and found signiﬁcant associations between features of the gut microbiome and lifestyle changes associated with economic development. These ﬁndings suggest that even the earliest stages of economic development can drive changes in the gut microbiome, which may provide a warning sign for the development of microbiome-associated diseases.
format	article
author	Keaton Stagaman Tara J. Cepon-Robins Melissa A. Liebert Theresa E. Gildner Samuel S. Urlacher Felicia C. Madimenos Karen Guillemin J. Josh Snodgrass Lawrence S. Sugiyama Brendan J. M. Bohannan
author_facet	Keaton Stagaman Tara J. Cepon-Robins Melissa A. Liebert Theresa E. Gildner Samuel S. Urlacher Felicia C. Madimenos Karen Guillemin J. Josh Snodgrass Lawrence S. Sugiyama Brendan J. M. Bohannan
author_sort	Keaton Stagaman
title	Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development
title_short	Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development
title_full	Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development
title_fullStr	Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development
title_full_unstemmed	Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development
title_sort	market integration predicts human gut microbiome attributes across a gradient of economic development
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/6b2b0ac1ec0b4de394f43653e5650e18
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Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development

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