Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.

<h4>Background</h4>Several studies have reported an association between single nucleotide polymorphisms in the first intron of the FTO gene and body mass index (BMI) or obesity. However, this association has not yet been studied among the Portuguese population. This study aims to assess...

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Autores principales:	David Albuquerque, Clévio Nóbrega, Licínio Manco
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b2cbf284353425493e46fb7d57690f6
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spelling	oai:doaj.org-article:6b2cbf284353425493e46fb7d57690f62021-11-18T08:01:28ZAssociation of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.1932-620310.1371/journal.pone.0054370https://doaj.org/article/6b2cbf284353425493e46fb7d57690f62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23342142/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several studies have reported an association between single nucleotide polymorphisms in the first intron of the FTO gene and body mass index (BMI) or obesity. However, this association has not yet been studied among the Portuguese population. This study aims to assess the association of three FTO polymorphisms (rs1861868, rs1421085 and rs9939609) with obesity-related outcomes in a sample of Portuguese children.<h4>Methods</h4>We examined a total of 730 children, 256 normal-weight (55.9% girls), 320 overweight (45.3% girls) and 154 obese (53.2% girls), aging from 6 to 12-years-old, recruited randomly from public schools in the central region of Portugal. DNA samples were genotyped for the three polymorphisms by allelic discrimination TaqMan assay. Association of the FTO polymorphisms with several anthropometric traits was investigated. Additionally, we tested association with the risk of obesity using overweight and obese vs. normal-weight children.<h4>Results</h4>We found significant associations of rs9939609 and rs1421085 polymorphisms with weight, BMI, BMI Z-score, waist circumference and hip circumference, even after age and gender adjustment (p<0.05 in all traits). For rs1861868 polymorphism, marginally significant associations were obtained with weight (p = 0.081) and BMI (p = 0.096) after adjustment for age and gender. In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05). Haplotype analyses identified two combinations (ACA and GCA) associated with a higher risk of obesity (OR 1.53; 95% CI, 1.06-2.22; p = 0.023; OR 1.73; 95% CI, 1.06-2.87; p = 0.030, respectively).<h4>Conclusions</h4>This study provides the first evidence for the association of FTO polymorphisms with anthropometric traits and risk of obesity in Portuguese children.David AlbuquerqueClévio NóbregaLicínio MancoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54370 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Albuquerque Clévio Nóbrega Licínio Manco Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
description	<h4>Background</h4>Several studies have reported an association between single nucleotide polymorphisms in the first intron of the FTO gene and body mass index (BMI) or obesity. However, this association has not yet been studied among the Portuguese population. This study aims to assess the association of three FTO polymorphisms (rs1861868, rs1421085 and rs9939609) with obesity-related outcomes in a sample of Portuguese children.<h4>Methods</h4>We examined a total of 730 children, 256 normal-weight (55.9% girls), 320 overweight (45.3% girls) and 154 obese (53.2% girls), aging from 6 to 12-years-old, recruited randomly from public schools in the central region of Portugal. DNA samples were genotyped for the three polymorphisms by allelic discrimination TaqMan assay. Association of the FTO polymorphisms with several anthropometric traits was investigated. Additionally, we tested association with the risk of obesity using overweight and obese vs. normal-weight children.<h4>Results</h4>We found significant associations of rs9939609 and rs1421085 polymorphisms with weight, BMI, BMI Z-score, waist circumference and hip circumference, even after age and gender adjustment (p<0.05 in all traits). For rs1861868 polymorphism, marginally significant associations were obtained with weight (p = 0.081) and BMI (p = 0.096) after adjustment for age and gender. In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05). Haplotype analyses identified two combinations (ACA and GCA) associated with a higher risk of obesity (OR 1.53; 95% CI, 1.06-2.22; p = 0.023; OR 1.73; 95% CI, 1.06-2.87; p = 0.030, respectively).<h4>Conclusions</h4>This study provides the first evidence for the association of FTO polymorphisms with anthropometric traits and risk of obesity in Portuguese children.
format	article
author	David Albuquerque Clévio Nóbrega Licínio Manco
author_facet	David Albuquerque Clévio Nóbrega Licínio Manco
author_sort	David Albuquerque
title	Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
title_short	Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
title_full	Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
title_fullStr	Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
title_full_unstemmed	Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
title_sort	association of fto polymorphisms with obesity and obesity-related outcomes in portuguese children.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6b2cbf284353425493e46fb7d57690f6
work_keys_str_mv	AT davidalbuquerque associationofftopolymorphismswithobesityandobesityrelatedoutcomesinportuguesechildren AT clevionobrega associationofftopolymorphismswithobesityandobesityrelatedoutcomesinportuguesechildren AT liciniomanco associationofftopolymorphismswithobesityandobesityrelatedoutcomesinportuguesechildren
_version_	1718422608593027072

Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.

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