Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites

Florina Pogacean,1 Alexandru R Biris,2 Maria Coros,1 Mihaela Diana Lazar,1 Fumiya Watanabe,3 Ganesh K Kannarpady,3 Said A Farha Al Said,4 Alexandru S Biris,3 Stela Pruneanu1 1Department of Isotopic Physics and Technology, 2Department of Mass Spectrometry, Chromatography, and Applied Physics, Nation...

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Autores principales:	Pogacean F, Biris AR, Coros M, Lazar MD, Watanabe F, Kannarpady GK, Al Said SA Farha, Biris AS, Pruneanu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b2e607ed43d41dbaf99a6b9f035d382
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spelling	oai:doaj.org-article:6b2e607ed43d41dbaf99a6b9f035d3822021-12-02T00:35:30ZDirect electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites1178-2013https://doaj.org/article/6b2e607ed43d41dbaf99a6b9f035d3822014-02-01T00:00:00Zhttp://www.dovepress.com/direct-electrochemical-oxidation-of-s-captopril-using-gold-electrodes--a15955https://doaj.org/toc/1178-2013 Florina Pogacean,1 Alexandru R Biris,2 Maria Coros,1 Mihaela Diana Lazar,1 Fumiya Watanabe,3 Ganesh K Kannarpady,3 Said A Farha Al Said,4 Alexandru S Biris,3 Stela Pruneanu1 1Department of Isotopic Physics and Technology, 2Department of Mass Spectrometry, Chromatography, and Applied Physics, National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania; 3Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, Arkansas, USA; 4Department of Physics, College of Science, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: In this paper, we present a novel approach for the electrochemical detection of S-captopril based on graphene AuAg nanostructures used to modify an Au electrode. Multi-layer graphene (Gr) sheets decorated with embedded bimetallic AuAg nanoparticles were successfully synthesized catalytically with methane as the carbon source. The two catalytic systems contained 1.0 wt% Ag and 1.0 wt% Au, while the second had a larger concentration of metals (1.5 wt% Ag and 1.5 wt% Au) and was used for the synthesis of the Gr-AuAg-1 and Gr-AuAg-1.5 multicomponent samples. High-resolution transmission electron microscopy analysis indicated the presence of graphene flakes that had regular shapes (square or rectangular) and dimensions in the tens to hundreds of nanometers. We found that the size of the embedded AuAg nanoparticles varied between 5 and 100 nm, with the majority being smaller than 20 nm. Advanced scanning transmission electron microscopy studies indicated a bimetallic characteristic of the metallic clusters. The resulting Gr-AuAg-1 and Gr-AuAg-1.5 samples were used to modify the surface of commonly used Au substrates and subsequently employed for the direct electrochemical oxidation of S-captopril. By comparing the differential pulse voltammograms recorded with the two modified electrodes at various concentrations of captopril, the peak current was determined to be well-defined, even at relatively low concentration (10-5 M), for the Au/Gr-AuAg-1.5 electrode. In contrast, the signals recorded with the Au/Gr-AuAg-1 electrode were poorly defined within a 5×10-6 to 5×10-3 M concentration range, and many of them overlapped with the background. Such composite materials could find significant applications in nanotechnology, sensing, or nanomedicine. Keywords: bimetallic AuAg nanoparticles, electrochemical detection, multi-layer graphenePogacean FBiris ARCoros MLazar MDWatanabe FKannarpady GKAl Said SA FarhaBiris ASPruneanu SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1111-1125 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Pogacean F Biris AR Coros M Lazar MD Watanabe F Kannarpady GK Al Said SA Farha Biris AS Pruneanu S Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites
description	Florina Pogacean,1 Alexandru R Biris,2 Maria Coros,1 Mihaela Diana Lazar,1 Fumiya Watanabe,3 Ganesh K Kannarpady,3 Said A Farha Al Said,4 Alexandru S Biris,3 Stela Pruneanu1 1Department of Isotopic Physics and Technology, 2Department of Mass Spectrometry, Chromatography, and Applied Physics, National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania; 3Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, Arkansas, USA; 4Department of Physics, College of Science, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: In this paper, we present a novel approach for the electrochemical detection of S-captopril based on graphene AuAg nanostructures used to modify an Au electrode. Multi-layer graphene (Gr) sheets decorated with embedded bimetallic AuAg nanoparticles were successfully synthesized catalytically with methane as the carbon source. The two catalytic systems contained 1.0 wt% Ag and 1.0 wt% Au, while the second had a larger concentration of metals (1.5 wt% Ag and 1.5 wt% Au) and was used for the synthesis of the Gr-AuAg-1 and Gr-AuAg-1.5 multicomponent samples. High-resolution transmission electron microscopy analysis indicated the presence of graphene flakes that had regular shapes (square or rectangular) and dimensions in the tens to hundreds of nanometers. We found that the size of the embedded AuAg nanoparticles varied between 5 and 100 nm, with the majority being smaller than 20 nm. Advanced scanning transmission electron microscopy studies indicated a bimetallic characteristic of the metallic clusters. The resulting Gr-AuAg-1 and Gr-AuAg-1.5 samples were used to modify the surface of commonly used Au substrates and subsequently employed for the direct electrochemical oxidation of S-captopril. By comparing the differential pulse voltammograms recorded with the two modified electrodes at various concentrations of captopril, the peak current was determined to be well-defined, even at relatively low concentration (10-5 M), for the Au/Gr-AuAg-1.5 electrode. In contrast, the signals recorded with the Au/Gr-AuAg-1 electrode were poorly defined within a 5×10-6 to 5×10-3 M concentration range, and many of them overlapped with the background. Such composite materials could find significant applications in nanotechnology, sensing, or nanomedicine. Keywords: bimetallic AuAg nanoparticles, electrochemical detection, multi-layer graphene
format	article
author	Pogacean F Biris AR Coros M Lazar MD Watanabe F Kannarpady GK Al Said SA Farha Biris AS Pruneanu S
author_facet	Pogacean F Biris AR Coros M Lazar MD Watanabe F Kannarpady GK Al Said SA Farha Biris AS Pruneanu S
author_sort	Pogacean F
title	Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites
title_short	Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites
title_full	Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites
title_fullStr	Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites
title_full_unstemmed	Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites
title_sort	direct electrochemical oxidation of s-captopril using gold electrodes modified with graphene-auag nanocomposites
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/6b2e607ed43d41dbaf99a6b9f035d382
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Direct electrochemical oxidation of S-captopril using gold electrodes modified with graphene-AuAg nanocomposites

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