Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model

In this manuscript, we elucidated, for the first time, the substructural mechanisms present in our recently developed bioinspired polyurethane-based pancreatic tissue models. Different protein coatings of the model, i.e., collagen and fibronectin were examined. More specifically, analysis took place...

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Autores principales:	Jingyi Mo, Nathanael Leung, Priyanka Gupta, Bin Zhu, Eirini Velliou, Tan Sui
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bioinspired polyurethane Surface functionalisation Synchrotron X-ray scattering techniques Confocal laser scanning microscopy In situ micromechanical testing Pancreatic cancer Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/6b2fe43cdacb4dc2ae609e5ae6d4d172
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spelling	oai:doaj.org-article:6b2fe43cdacb4dc2ae609e5ae6d4d1722021-11-04T04:39:07ZNovel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model2590-049810.1016/j.mtadv.2021.100184https://doaj.org/article/6b2fe43cdacb4dc2ae609e5ae6d4d1722021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590049821000540https://doaj.org/toc/2590-0498In this manuscript, we elucidated, for the first time, the substructural mechanisms present in our recently developed bioinspired polyurethane-based pancreatic tissue models. Different protein coatings of the model, i.e., collagen and fibronectin were examined. More specifically, analysis took place by combined real-time synchrotron X-ray scattering techniques and confocal laser scanning microscopy, to quantify the structural alteration of uncoated-polyurethane (PU) and protein-coated PU as well as the time-resolved structural reorganisation occurring at the micro-, nano- and lattice length scales during in situ micromechanical testing. We demonstrate that a clear increase of stiffness at the lamellar level following the fibronectin-PU modification, which is linked to the changes in the mechanics of the lamellae and interlamellar cohesion. This multi-level analysis of structural-mechanical relations in this polyurethane-based pancreatic cancer tissue model opens an opportunity in designing mechanically robust cost-effective tissue models not only for fundamental research but also for treatment screening.Jingyi MoNathanael LeungPriyanka GuptaBin ZhuEirini VelliouTan SuiElsevierarticleBioinspired polyurethaneSurface functionalisationSynchrotron X-ray scattering techniquesConfocal laser scanning microscopyIn situ micromechanical testingPancreatic cancerMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials Today Advances, Vol 12, Iss , Pp 100184- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bioinspired polyurethane Surface functionalisation Synchrotron X-ray scattering techniques Confocal laser scanning microscopy In situ micromechanical testing Pancreatic cancer Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Bioinspired polyurethane Surface functionalisation Synchrotron X-ray scattering techniques Confocal laser scanning microscopy In situ micromechanical testing Pancreatic cancer Materials of engineering and construction. Mechanics of materials TA401-492 Jingyi Mo Nathanael Leung Priyanka Gupta Bin Zhu Eirini Velliou Tan Sui Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
description	In this manuscript, we elucidated, for the first time, the substructural mechanisms present in our recently developed bioinspired polyurethane-based pancreatic tissue models. Different protein coatings of the model, i.e., collagen and fibronectin were examined. More specifically, analysis took place by combined real-time synchrotron X-ray scattering techniques and confocal laser scanning microscopy, to quantify the structural alteration of uncoated-polyurethane (PU) and protein-coated PU as well as the time-resolved structural reorganisation occurring at the micro-, nano- and lattice length scales during in situ micromechanical testing. We demonstrate that a clear increase of stiffness at the lamellar level following the fibronectin-PU modification, which is linked to the changes in the mechanics of the lamellae and interlamellar cohesion. This multi-level analysis of structural-mechanical relations in this polyurethane-based pancreatic cancer tissue model opens an opportunity in designing mechanically robust cost-effective tissue models not only for fundamental research but also for treatment screening.
format	article
author	Jingyi Mo Nathanael Leung Priyanka Gupta Bin Zhu Eirini Velliou Tan Sui
author_facet	Jingyi Mo Nathanael Leung Priyanka Gupta Bin Zhu Eirini Velliou Tan Sui
author_sort	Jingyi Mo
title	Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
title_short	Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
title_full	Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
title_fullStr	Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
title_full_unstemmed	Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
title_sort	novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6b2fe43cdacb4dc2ae609e5ae6d4d172
work_keys_str_mv	AT jingyimo novelinsitumultilevelanalysisofstructuralmechanicalrelationsinabioinspiredpolyurethanebasedtissuemodel AT nathanaelleung novelinsitumultilevelanalysisofstructuralmechanicalrelationsinabioinspiredpolyurethanebasedtissuemodel AT priyankagupta novelinsitumultilevelanalysisofstructuralmechanicalrelationsinabioinspiredpolyurethanebasedtissuemodel AT binzhu novelinsitumultilevelanalysisofstructuralmechanicalrelationsinabioinspiredpolyurethanebasedtissuemodel AT eirinivelliou novelinsitumultilevelanalysisofstructuralmechanicalrelationsinabioinspiredpolyurethanebasedtissuemodel AT tansui novelinsitumultilevelanalysisofstructuralmechanicalrelationsinabioinspiredpolyurethanebasedtissuemodel
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Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model

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