FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY

Abstract. A complex immunologic examination of fifty patients with clinically significant postoperative fibrosis has been performed. Immunogram indexes were determined, and activities of basic oxidation-reduction enzymes were investigated in blood lymphocytes. What concerned immune status of the pat...

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Autores principales:	N. V. Isaeva, G. V. Bulygin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	lymphocytes metabolic parameters epidural fibrosis immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6b34ef6fc2034e04b88c6a3983124771
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spelling	oai:doaj.org-article:6b34ef6fc2034e04b88c6a39831247712021-11-18T08:03:39ZFEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY1563-06252313-741X10.15789/1563-0625-2008-6-589-592https://doaj.org/article/6b34ef6fc2034e04b88c6a39831247712014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/252https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A complex immunologic examination of fifty patients with clinically significant postoperative fibrosis has been performed. Immunogram indexes were determined, and activities of basic oxidation-reduction enzymes were investigated in blood lymphocytes. What concerned immune status of the patients under study, some peculiar features have been revealed, with respect to cellular and humoral compartments, i.e., relative increase in CD3+ population, a shift to CD4+ cells in the ratio of lymphocyte subpopulations, higher indexes of immune regulation and phagocytosis, increased IgG level, and lower content of IgA, as compared to appropriate controls. Metabolic parameters of lymphocytes reflect their functional activation, being expressed as an enhanced ability for intracellular synthetic processes, elevated functional activity of lymphocytes, and increased immune response. The general pattern of changes in immune status and metabolic indexes of lymphocytes allow us to assume participation of autoimmune component in progression of epidural fibrosis. The data obtained may be used in combined diagnostics and correction of this disorder. (Med. Immunol., vol. 10, N 6, pp 589-592).N. V. IsaevaG. V. BulyginSPb RAACIarticlelymphocytes metabolic parametersepidural fibrosisimmunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 589-592 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes metabolic parameters epidural fibrosis immunity Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocytes metabolic parameters epidural fibrosis immunity Immunologic diseases. Allergy RC581-607 N. V. Isaeva G. V. Bulygin FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY
description	Abstract. A complex immunologic examination of fifty patients with clinically significant postoperative fibrosis has been performed. Immunogram indexes were determined, and activities of basic oxidation-reduction enzymes were investigated in blood lymphocytes. What concerned immune status of the patients under study, some peculiar features have been revealed, with respect to cellular and humoral compartments, i.e., relative increase in CD3+ population, a shift to CD4+ cells in the ratio of lymphocyte subpopulations, higher indexes of immune regulation and phagocytosis, increased IgG level, and lower content of IgA, as compared to appropriate controls. Metabolic parameters of lymphocytes reflect their functional activation, being expressed as an enhanced ability for intracellular synthetic processes, elevated functional activity of lymphocytes, and increased immune response. The general pattern of changes in immune status and metabolic indexes of lymphocytes allow us to assume participation of autoimmune component in progression of epidural fibrosis. The data obtained may be used in combined diagnostics and correction of this disorder. (Med. Immunol., vol. 10, N 6, pp 589-592).
format	article
author	N. V. Isaeva G. V. Bulygin
author_facet	N. V. Isaeva G. V. Bulygin
author_sort	N. V. Isaeva
title	FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY
title_short	FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY
title_full	FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY
title_fullStr	FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY
title_full_unstemmed	FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY
title_sort	features of metabolic indexes of blood lymphocytes in the patients with epidural fibrosis following lumbar microdiscectomy
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/6b34ef6fc2034e04b88c6a3983124771
work_keys_str_mv	AT nvisaeva featuresofmetabolicindexesofbloodlymphocytesinthepatientswithepiduralfibrosisfollowinglumbarmicrodiscectomy AT gvbulygin featuresofmetabolicindexesofbloodlymphocytesinthepatientswithepiduralfibrosisfollowinglumbarmicrodiscectomy
_version_	1718422549691367424

FEATURES OF METABOLIC INDEXES OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH EPIDURAL FIBROSIS FOLLOWING LUMBAR MICRODISCECTOMY

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