Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors.
<h4>Background</h4>HIV-infected controllers control viral replication and maintain normal CD4+ T cell counts. Long Term Non-Progressors (LTNP) also maintain normal CD4+ T cell counts, but have on-going viral replication. We hypothesized that different immunological mechanisms are respons...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6b368105cbb54f4da6187f0af308520f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6b368105cbb54f4da6187f0af308520f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6b368105cbb54f4da6187f0af308520f2021-11-18T07:45:28ZDifferent immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors.1932-620310.1371/journal.pone.0063744https://doaj.org/article/6b368105cbb54f4da6187f0af308520f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23696852/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>HIV-infected controllers control viral replication and maintain normal CD4+ T cell counts. Long Term Non-Progressors (LTNP) also maintain normal CD4+ T cell counts, but have on-going viral replication. We hypothesized that different immunological mechanisms are responsible for preserved CD4+ T cell counts in controllers and LTNP.<h4>Methods</h4>25 HIV-infected controllers and 14 LTNP were included in this cross-sectional study. For comparison, 25 progressors and 34 healthy controls were included. Production and destruction of T cells were addressed by determination of T cell receptor excision circles (TREC), recent thymic emigrants, naïve cells, immune activation, senescence and apoptosis. Furthermore, telomere length was determined, and the amount of lymphoid tissue in tonsil biopsies was quantified.<h4>Results</h4>Controllers presented with partly preserved thymic output, preserved expression of the IL-7 receptor and IL-7 receptor density, and lower levels of destruction of cells than progressors resembling HIV-negative healthy controls. In contrast, LTNP appeared much like progressors, and different from controllers in immune activation, senescence, and apoptosis. Interestingly, CD8+ RTE, TREC and telomere length were partly preserved. Finally, both controllers and LTNP displayed decreased amounts of lymphoid tissue compared to healthy controls.<h4>Conclusions</h4>Controllers presented with an immunological profile different from LTNP. While controllers resembled healthy controls, LTNP were similar to progressors, suggesting different immunological mechanisms to be responsible for preserved CD4+ T cell counts in LTNP and controllers. However, both controllers and LTNP presented with reduced amounts of lymphoid tissue despite preserved CD4+ T cell counts, indicating HIV to cause damage even in non-progressors.Julie Christine GaardboHans J HartlingAndreas RonitKristina ThorsteinssonHans Ole MadsenKaroline SpringborgLise Mette Rahbek GjerdrumCarsten BirchMatthew LayeHenrik UllumÅse Bengaard AndersenSusanne Dam NielsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63744 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Julie Christine Gaardbo Hans J Hartling Andreas Ronit Kristina Thorsteinsson Hans Ole Madsen Karoline Springborg Lise Mette Rahbek Gjerdrum Carsten Birch Matthew Laye Henrik Ullum Åse Bengaard Andersen Susanne Dam Nielsen Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors. |
| description |
<h4>Background</h4>HIV-infected controllers control viral replication and maintain normal CD4+ T cell counts. Long Term Non-Progressors (LTNP) also maintain normal CD4+ T cell counts, but have on-going viral replication. We hypothesized that different immunological mechanisms are responsible for preserved CD4+ T cell counts in controllers and LTNP.<h4>Methods</h4>25 HIV-infected controllers and 14 LTNP were included in this cross-sectional study. For comparison, 25 progressors and 34 healthy controls were included. Production and destruction of T cells were addressed by determination of T cell receptor excision circles (TREC), recent thymic emigrants, naïve cells, immune activation, senescence and apoptosis. Furthermore, telomere length was determined, and the amount of lymphoid tissue in tonsil biopsies was quantified.<h4>Results</h4>Controllers presented with partly preserved thymic output, preserved expression of the IL-7 receptor and IL-7 receptor density, and lower levels of destruction of cells than progressors resembling HIV-negative healthy controls. In contrast, LTNP appeared much like progressors, and different from controllers in immune activation, senescence, and apoptosis. Interestingly, CD8+ RTE, TREC and telomere length were partly preserved. Finally, both controllers and LTNP displayed decreased amounts of lymphoid tissue compared to healthy controls.<h4>Conclusions</h4>Controllers presented with an immunological profile different from LTNP. While controllers resembled healthy controls, LTNP were similar to progressors, suggesting different immunological mechanisms to be responsible for preserved CD4+ T cell counts in LTNP and controllers. However, both controllers and LTNP presented with reduced amounts of lymphoid tissue despite preserved CD4+ T cell counts, indicating HIV to cause damage even in non-progressors. |
| format |
article |
| author |
Julie Christine Gaardbo Hans J Hartling Andreas Ronit Kristina Thorsteinsson Hans Ole Madsen Karoline Springborg Lise Mette Rahbek Gjerdrum Carsten Birch Matthew Laye Henrik Ullum Åse Bengaard Andersen Susanne Dam Nielsen |
| author_facet |
Julie Christine Gaardbo Hans J Hartling Andreas Ronit Kristina Thorsteinsson Hans Ole Madsen Karoline Springborg Lise Mette Rahbek Gjerdrum Carsten Birch Matthew Laye Henrik Ullum Åse Bengaard Andersen Susanne Dam Nielsen |
| author_sort |
Julie Christine Gaardbo |
| title |
Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors. |
| title_short |
Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors. |
| title_full |
Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors. |
| title_fullStr |
Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors. |
| title_full_unstemmed |
Different immunological phenotypes associated with preserved CD4+ T cell counts in HIV-infected controllers and viremic long term non-progressors. |
| title_sort |
different immunological phenotypes associated with preserved cd4+ t cell counts in hiv-infected controllers and viremic long term non-progressors. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/6b368105cbb54f4da6187f0af308520f |
| work_keys_str_mv |
AT juliechristinegaardbo differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT hansjhartling differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT andreasronit differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT kristinathorsteinsson differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT hansolemadsen differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT karolinespringborg differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT lisemetterahbekgjerdrum differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT carstenbirch differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT matthewlaye differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT henrikullum differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT asebengaardandersen differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors AT susannedamnielsen differentimmunologicalphenotypesassociatedwithpreservedcd4tcellcountsinhivinfectedcontrollersandviremiclongtermnonprogressors |
| _version_ |
1718422977303805952 |