CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells

Matos et al characterise previously developed cholesterol analogues, named CHIMs, which can be fluorescently labelled by click-chemistry. They find that CHIMs segregate similarly to cholesterol in lipid bilayers, allow the visualisation of cholesterol dynamics in cells, and can functionally replace...

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Autores principales:	Anna L. L. Matos, Fabian Keller, Tristan Wegner, Carla Elizabeth Cadena del Castillo, David Grill, Sergej Kudruk, Anne Spang, Frank Glorius, Andreas Heuer, Volker Gerke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6b36ae3d947f489d9b59bc1192d85ba4
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spelling	oai:doaj.org-article:6b36ae3d947f489d9b59bc1192d85ba42021-12-02T17:30:53ZCHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells10.1038/s42003-021-02252-52399-3642https://doaj.org/article/6b36ae3d947f489d9b59bc1192d85ba42021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02252-5https://doaj.org/toc/2399-3642Matos et al characterise previously developed cholesterol analogues, named CHIMs, which can be fluorescently labelled by click-chemistry. They find that CHIMs segregate similarly to cholesterol in lipid bilayers, allow the visualisation of cholesterol dynamics in cells, and can functionally replace cholesterol in C.elegans.Anna L. L. MatosFabian KellerTristan WegnerCarla Elizabeth Cadena del CastilloDavid GrillSergej KudrukAnne SpangFrank GloriusAndreas HeuerVolker GerkeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anna L. L. Matos Fabian Keller Tristan Wegner Carla Elizabeth Cadena del Castillo David Grill Sergej Kudruk Anne Spang Frank Glorius Andreas Heuer Volker Gerke CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
description	Matos et al characterise previously developed cholesterol analogues, named CHIMs, which can be fluorescently labelled by click-chemistry. They find that CHIMs segregate similarly to cholesterol in lipid bilayers, allow the visualisation of cholesterol dynamics in cells, and can functionally replace cholesterol in C.elegans.
format	article
author	Anna L. L. Matos Fabian Keller Tristan Wegner Carla Elizabeth Cadena del Castillo David Grill Sergej Kudruk Anne Spang Frank Glorius Andreas Heuer Volker Gerke
author_facet	Anna L. L. Matos Fabian Keller Tristan Wegner Carla Elizabeth Cadena del Castillo David Grill Sergej Kudruk Anne Spang Frank Glorius Andreas Heuer Volker Gerke
author_sort	Anna L. L. Matos
title	CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
title_short	CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
title_full	CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
title_fullStr	CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
title_full_unstemmed	CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
title_sort	chims are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b36ae3d947f489d9b59bc1192d85ba4
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CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells

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