Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

Kinesin-1 is a motor protein transporting cargo along microtubules. Here the authors show that kinesin-1 is required for antigen cross-presentation and coordinates endosome scission from early endosomes to allow sorting internalized cargoes towards the recycling endosomal or lysosomal compartments.

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Autores principales: Meriem Belabed, François-Xavier Mauvais, Sophia Maschalidi, Mathieu Kurowska, Nicolas Goudin, Jian-Dong Huang, Alain Fischer, Geneviève de Saint Basile, Peter van Endert, Fernando E. Sepulveda, Gaël Ménasché
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/6b390d25f10f4b0fa7554f33d2fe6480
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spelling oai:doaj.org-article:6b390d25f10f4b0fa7554f33d2fe64802021-12-02T14:41:04ZKinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells10.1038/s41467-020-15692-02041-1723https://doaj.org/article/6b390d25f10f4b0fa7554f33d2fe64802020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15692-0https://doaj.org/toc/2041-1723Kinesin-1 is a motor protein transporting cargo along microtubules. Here the authors show that kinesin-1 is required for antigen cross-presentation and coordinates endosome scission from early endosomes to allow sorting internalized cargoes towards the recycling endosomal or lysosomal compartments.Meriem BelabedFrançois-Xavier MauvaisSophia MaschalidiMathieu KurowskaNicolas GoudinJian-Dong HuangAlain FischerGeneviève de Saint BasilePeter van EndertFernando E. SepulvedaGaël MénaschéNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meriem Belabed
François-Xavier Mauvais
Sophia Maschalidi
Mathieu Kurowska
Nicolas Goudin
Jian-Dong Huang
Alain Fischer
Geneviève de Saint Basile
Peter van Endert
Fernando E. Sepulveda
Gaël Ménasché
Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
description Kinesin-1 is a motor protein transporting cargo along microtubules. Here the authors show that kinesin-1 is required for antigen cross-presentation and coordinates endosome scission from early endosomes to allow sorting internalized cargoes towards the recycling endosomal or lysosomal compartments.
format article
author Meriem Belabed
François-Xavier Mauvais
Sophia Maschalidi
Mathieu Kurowska
Nicolas Goudin
Jian-Dong Huang
Alain Fischer
Geneviève de Saint Basile
Peter van Endert
Fernando E. Sepulveda
Gaël Ménasché
author_facet Meriem Belabed
François-Xavier Mauvais
Sophia Maschalidi
Mathieu Kurowska
Nicolas Goudin
Jian-Dong Huang
Alain Fischer
Geneviève de Saint Basile
Peter van Endert
Fernando E. Sepulveda
Gaël Ménasché
author_sort Meriem Belabed
title Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
title_short Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
title_full Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
title_fullStr Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
title_full_unstemmed Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
title_sort kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6b390d25f10f4b0fa7554f33d2fe6480
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