Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine

ABSTRACT The molecular epidemiology of culture-confirmed invasive meningococcal disease (IMD) in Canada from 2010 to 2014 was studied with an emphasis on serogroup B Neisseria meningitidis (MenB) isolates, including their predicted coverage by the 4CMenB vaccine. The mean annual incidence rates of c...

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Autores principales:	Raymond S. W. Tsang, Dennis K. S. Law, Rosita De Paola, Maria Giuliani, Maria Stella, Jianwei Zhou, Saul Deng, Giuseppe Boccadifuoco, Marzia Monica Giuliani, Laura Serino
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	serogroup B MATS assay disease invasive meningococcal Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6b3e93bc5d6c4392827b8a03489a4380
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spelling	oai:doaj.org-article:6b3e93bc5d6c4392827b8a03489a43802021-11-15T15:29:16ZCulture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine10.1128/mSphere.00883-192379-5042https://doaj.org/article/6b3e93bc5d6c4392827b8a03489a43802020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00883-19https://doaj.org/toc/2379-5042ABSTRACT The molecular epidemiology of culture-confirmed invasive meningococcal disease (IMD) in Canada from 2010 to 2014 was studied with an emphasis on serogroup B Neisseria meningitidis (MenB) isolates, including their predicted coverage by the 4CMenB vaccine. The mean annual incidence rates of culture confirmed IMD varied from 0.19/100,000 in Ontario to 0.50/100,000 in New Brunswick and 0.59/100,000 in Quebec. In both Quebec and Atlantic region, MenB was significantly more common than other serogroups, while in other provinces, both MenB and serogroup Y (MenY) were almost equally common. The majority of MenB cases (67.0%) were in those aged ≤24 years, while most MenC (75.0%) and MenY (69.6%) cases were in adults more than 24 years old. The 349 MenB isolates were grouped into 103 sequence types (STs), 90 of which belonged to 13 clonal complexes (CCs). A large number of 4CMenB antigen genes were found among the Canadian MenB, which is predicted to encode 50 factor H binding protein (fHbp) types, 40 NHBA types, and 55 PorA genotypes. Provinces and regions were found to have their own unique MenB STs. A meningococcal antigen typing system assay predicted an overall MenB coverage by 4CMenB to be 73.6%, with higher coverage predicted for the two most common STs: 100% for ST154 and 95.9% for ST269, leading to higher coverage in both the Atlantic region and Quebec. Higher coverage (81.4%) was also found for MenB recovered from persons aged 15 to 24 years, followed by strains from infants and children ≤4 years old (75.2%) and those aged 5 to 14 years (75.0%). IMPORTANCE Laboratory surveillance of invasive meningococcal disease (IMD) is important to our understanding of the evolving nature of the Neisseria meningitidis strain types causing the disease and the potential coverage of disease strains by the newly developed vaccines. This study examined the molecular epidemiology of culture-confirmed IMD cases in Canada by examining the strain types and the potential coverage of a newly licensed 4CMenB vaccine on Canadian serogroup B N. meningitidis strains. The strain types identified in different parts of Canada appeared to be unique as well as their predicted coverage by the 4CMenB vaccine. These data were compared to data obtained from previous studies done in Canada and elsewhere globally. For effective control of IMD, laboratory surveillance of this type was found to be essential and useful to understand the dynamic nature of this disease.Raymond S. W. TsangDennis K. S. LawRosita De PaolaMaria GiulianiMaria StellaJianwei ZhouSaul DengGiuseppe BoccadifuocoMarzia Monica GiulianiLaura SerinoAmerican Society for Microbiologyarticleserogroup BMATS assaydiseaseinvasivemeningococcalMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	serogroup B MATS assay disease invasive meningococcal Microbiology QR1-502
spellingShingle	serogroup B MATS assay disease invasive meningococcal Microbiology QR1-502 Raymond S. W. Tsang Dennis K. S. Law Rosita De Paola Maria Giuliani Maria Stella Jianwei Zhou Saul Deng Giuseppe Boccadifuoco Marzia Monica Giuliani Laura Serino Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine
description	ABSTRACT The molecular epidemiology of culture-confirmed invasive meningococcal disease (IMD) in Canada from 2010 to 2014 was studied with an emphasis on serogroup B Neisseria meningitidis (MenB) isolates, including their predicted coverage by the 4CMenB vaccine. The mean annual incidence rates of culture confirmed IMD varied from 0.19/100,000 in Ontario to 0.50/100,000 in New Brunswick and 0.59/100,000 in Quebec. In both Quebec and Atlantic region, MenB was significantly more common than other serogroups, while in other provinces, both MenB and serogroup Y (MenY) were almost equally common. The majority of MenB cases (67.0%) were in those aged ≤24 years, while most MenC (75.0%) and MenY (69.6%) cases were in adults more than 24 years old. The 349 MenB isolates were grouped into 103 sequence types (STs), 90 of which belonged to 13 clonal complexes (CCs). A large number of 4CMenB antigen genes were found among the Canadian MenB, which is predicted to encode 50 factor H binding protein (fHbp) types, 40 NHBA types, and 55 PorA genotypes. Provinces and regions were found to have their own unique MenB STs. A meningococcal antigen typing system assay predicted an overall MenB coverage by 4CMenB to be 73.6%, with higher coverage predicted for the two most common STs: 100% for ST154 and 95.9% for ST269, leading to higher coverage in both the Atlantic region and Quebec. Higher coverage (81.4%) was also found for MenB recovered from persons aged 15 to 24 years, followed by strains from infants and children ≤4 years old (75.2%) and those aged 5 to 14 years (75.0%). IMPORTANCE Laboratory surveillance of invasive meningococcal disease (IMD) is important to our understanding of the evolving nature of the Neisseria meningitidis strain types causing the disease and the potential coverage of disease strains by the newly developed vaccines. This study examined the molecular epidemiology of culture-confirmed IMD cases in Canada by examining the strain types and the potential coverage of a newly licensed 4CMenB vaccine on Canadian serogroup B N. meningitidis strains. The strain types identified in different parts of Canada appeared to be unique as well as their predicted coverage by the 4CMenB vaccine. These data were compared to data obtained from previous studies done in Canada and elsewhere globally. For effective control of IMD, laboratory surveillance of this type was found to be essential and useful to understand the dynamic nature of this disease.
format	article
author	Raymond S. W. Tsang Dennis K. S. Law Rosita De Paola Maria Giuliani Maria Stella Jianwei Zhou Saul Deng Giuseppe Boccadifuoco Marzia Monica Giuliani Laura Serino
author_facet	Raymond S. W. Tsang Dennis K. S. Law Rosita De Paola Maria Giuliani Maria Stella Jianwei Zhou Saul Deng Giuseppe Boccadifuoco Marzia Monica Giuliani Laura Serino
author_sort	Raymond S. W. Tsang
title	Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine
title_short	Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine
title_full	Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine
title_fullStr	Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine
title_full_unstemmed	Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine
title_sort	culture-confirmed invasive meningococcal disease in canada, 2010 to 2014: characterization of serogroup b <italic toggle="yes">neisseria meningitidis</italic> strains and their predicted coverage by the 4cmenb vaccine
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/6b3e93bc5d6c4392827b8a03489a4380
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Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup B <italic toggle="yes">Neisseria meningitidis</italic> Strains and Their Predicted Coverage by the 4CMenB Vaccine

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