In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats

Introduction Piper sarmentosum (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats expo...

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Autores principales:	Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Muhamad Nurul Akmal, Ibrahim Abdel Aziz Ibrahim, Yusof Kamisah
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	oxidative stress stress gastric ulcers prostaglandins piper sarmentosum Medicine R
Acceso en línea:	https://doaj.org/article/6b449f8c80c94b5b8f13290371062738
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spelling	oai:doaj.org-article:6b449f8c80c94b5b8f132903710627382021-12-02T16:58:24ZIn vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats1734-19221896-915110.5114/aoms.2016.63156https://doaj.org/article/6b449f8c80c94b5b8f132903710627382018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/In-vivo-effect-of-Piper-sarmentosum-methanolic-extract-on-stress-induced-gastric,64170,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Piper sarmentosum (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress. Material and methods The methanolic extract of PS was prepared in the dose of 500 mg/kg. Twenty-eight male Wistar rats were assigned to 4 equal sized groups: two control groups and two treated groups which were supplemented with either PS or OMZ orally at a dose of 500 mg/kg and 20 mg/kg body weight respectively. After 28 days of treatment, one control group, the PS and OMZ group were subjected to a single exposure of water-immersion restraint stress for 3.5 h. After the last exposure to stress, the stomach was excised for evaluation of the parameters. Results Oral supplementation of PS was as effective in preventing the formation of gastric lesion when compared with OMZ (p < 0.05). The increased gastric acidity and MDA due to stress was also reduced with supplementation of PS and OMZ. Only PS had the ability to reduce prostaglandin E2 loss (p = 0.0067) and have the ability to down regulate cyclooxygenase-2 (COX-2) mRNA expression (p = 0.01) with stress exposure. Conclusions Piper sarmentosum possesses a similar protective effect against stress-induced gastric lesions as omeprazole. The protective effect was associated with decreased lipid peroxidation, increased prostaglandin E2, reduction in gastric acidity and reduction in COX-2 mRNA expression which was altered by stress.Mohd Fahami Nur AzlinaHj Mohd Saad QodriyahMuhamad Nurul AkmalIbrahim Abdel Aziz IbrahimYusof KamisahTermedia Publishing Housearticleoxidative stressstressgastric ulcersprostaglandinspiper sarmentosumoxidative stressMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 223-231 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress stress gastric ulcers prostaglandins piper sarmentosum oxidative stress Medicine R
spellingShingle	oxidative stress stress gastric ulcers prostaglandins piper sarmentosum oxidative stress Medicine R Mohd Fahami Nur Azlina Hj Mohd Saad Qodriyah Muhamad Nurul Akmal Ibrahim Abdel Aziz Ibrahim Yusof Kamisah In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
description	Introduction Piper sarmentosum (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress. Material and methods The methanolic extract of PS was prepared in the dose of 500 mg/kg. Twenty-eight male Wistar rats were assigned to 4 equal sized groups: two control groups and two treated groups which were supplemented with either PS or OMZ orally at a dose of 500 mg/kg and 20 mg/kg body weight respectively. After 28 days of treatment, one control group, the PS and OMZ group were subjected to a single exposure of water-immersion restraint stress for 3.5 h. After the last exposure to stress, the stomach was excised for evaluation of the parameters. Results Oral supplementation of PS was as effective in preventing the formation of gastric lesion when compared with OMZ (p < 0.05). The increased gastric acidity and MDA due to stress was also reduced with supplementation of PS and OMZ. Only PS had the ability to reduce prostaglandin E2 loss (p = 0.0067) and have the ability to down regulate cyclooxygenase-2 (COX-2) mRNA expression (p = 0.01) with stress exposure. Conclusions Piper sarmentosum possesses a similar protective effect against stress-induced gastric lesions as omeprazole. The protective effect was associated with decreased lipid peroxidation, increased prostaglandin E2, reduction in gastric acidity and reduction in COX-2 mRNA expression which was altered by stress.
format	article
author	Mohd Fahami Nur Azlina Hj Mohd Saad Qodriyah Muhamad Nurul Akmal Ibrahim Abdel Aziz Ibrahim Yusof Kamisah
author_facet	Mohd Fahami Nur Azlina Hj Mohd Saad Qodriyah Muhamad Nurul Akmal Ibrahim Abdel Aziz Ibrahim Yusof Kamisah
author_sort	Mohd Fahami Nur Azlina
title	In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
title_short	In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
title_full	In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
title_fullStr	In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
title_full_unstemmed	In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
title_sort	in vivo effect of piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/6b449f8c80c94b5b8f13290371062738
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In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats

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