Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy

Xiaowei Wang, Yuhan Qiu, Mengyan Wang, Conghui Zhang, Tianshu Zhang, Huimin Zhou, Wenxia Zhao, Wuli Zhao, Guimin Xia, Rongguang Shao Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence...

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Autores principales:	Wang X, Qiu Y, Wang M, Zhang C, Zhang T, Zhou H, Zhao W, Xia G, Shao R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanomedicine endocytosis pathway clathrin caveolae endosome organelle targeting Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6b44f3e6bf774ef786de3851d6e15f5e
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spelling	oai:doaj.org-article:6b44f3e6bf774ef786de3851d6e15f5e2021-12-02T12:02:19ZEndocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy1178-2013https://doaj.org/article/6b44f3e6bf774ef786de3851d6e15f5e2020-11-01T00:00:00Zhttps://www.dovepress.com/endocytosis-and-organelle-targeting-of-nanomedicines-in-cancer-therapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaowei Wang, Yuhan Qiu, Mengyan Wang, Conghui Zhang, Tianshu Zhang, Huimin Zhou, Wenxia Zhao, Wuli Zhao, Guimin Xia, Rongguang Shao Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Wuli ZhaoInstitute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 10050, People’s Republic of ChinaTel +86-10-83166673Email zwl21146@imb.pumc.edu.cnGuimin XiaInstitute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 10050, People’s Republic of ChinaTel +86-10-63150697Email xiaguimin@126.comAbstract: Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by tumor cells is usually a prerequisite to deliver the cargo to intracellular locations, which mainly relies on endocytosis. NMs can enter cells through a variety of endocytosis pathways. Different endocytosis pathways exhibit different intracellular trafficking routes and diverse subcellular localizations. Therefore, a comprehensive understanding of endocytosis mechanisms is necessary for increasing cellular entry efficiency and to trace the fate of NMs after internalization. This review focuses on endocytosis pathways of NMs in tumor cells, mainly including clathrin- and caveolae-mediated endocytosis pathways, involving effector molecules, expression difference of those molecules between normal and tumor cells, as well as the intracellular trafficking route of corresponding endocytosis vesicles. Then, the latest strategies for NMs to actively employ endocytosis are described, including improving tumor cellular uptake of NMs by receptor-mediated endocytosis, transporter-mediated endocytosis and enabling drug activity by changing intracellular routes. Finally, active targeting strategies towards intracellular organelles are also mentioned. This review will be helpful not only in explicating endocytosis and the trafficking process of NMs and elucidating anti-tumor mechanisms inside the cell but also in rendering new ideas for the design of highly efﬁcacious and cancer-targeted NMs.Keywords: nanomedicine, endocytosis pathway, clathrin, caveolae, endosome, organelle targetingWang XQiu YWang MZhang CZhang TZhou HZhao WZhao WXia GShao RDove Medical Pressarticlenanomedicineendocytosis pathwayclathrincaveolaeendosomeorganelle targetingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9447-9467 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomedicine endocytosis pathway clathrin caveolae endosome organelle targeting Medicine (General) R5-920
spellingShingle	nanomedicine endocytosis pathway clathrin caveolae endosome organelle targeting Medicine (General) R5-920 Wang X Qiu Y Wang M Zhang C Zhang T Zhou H Zhao W Zhao W Xia G Shao R Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
description	Xiaowei Wang, Yuhan Qiu, Mengyan Wang, Conghui Zhang, Tianshu Zhang, Huimin Zhou, Wenxia Zhao, Wuli Zhao, Guimin Xia, Rongguang Shao Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Wuli ZhaoInstitute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 10050, People’s Republic of ChinaTel +86-10-83166673Email zwl21146@imb.pumc.edu.cnGuimin XiaInstitute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 10050, People’s Republic of ChinaTel +86-10-63150697Email xiaguimin@126.comAbstract: Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by tumor cells is usually a prerequisite to deliver the cargo to intracellular locations, which mainly relies on endocytosis. NMs can enter cells through a variety of endocytosis pathways. Different endocytosis pathways exhibit different intracellular trafficking routes and diverse subcellular localizations. Therefore, a comprehensive understanding of endocytosis mechanisms is necessary for increasing cellular entry efficiency and to trace the fate of NMs after internalization. This review focuses on endocytosis pathways of NMs in tumor cells, mainly including clathrin- and caveolae-mediated endocytosis pathways, involving effector molecules, expression difference of those molecules between normal and tumor cells, as well as the intracellular trafficking route of corresponding endocytosis vesicles. Then, the latest strategies for NMs to actively employ endocytosis are described, including improving tumor cellular uptake of NMs by receptor-mediated endocytosis, transporter-mediated endocytosis and enabling drug activity by changing intracellular routes. Finally, active targeting strategies towards intracellular organelles are also mentioned. This review will be helpful not only in explicating endocytosis and the trafficking process of NMs and elucidating anti-tumor mechanisms inside the cell but also in rendering new ideas for the design of highly efﬁcacious and cancer-targeted NMs.Keywords: nanomedicine, endocytosis pathway, clathrin, caveolae, endosome, organelle targeting
format	article
author	Wang X Qiu Y Wang M Zhang C Zhang T Zhou H Zhao W Zhao W Xia G Shao R
author_facet	Wang X Qiu Y Wang M Zhang C Zhang T Zhou H Zhao W Zhao W Xia G Shao R
author_sort	Wang X
title	Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
title_short	Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
title_full	Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
title_fullStr	Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
title_full_unstemmed	Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
title_sort	endocytosis and organelle targeting of nanomedicines in cancer therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6b44f3e6bf774ef786de3851d6e15f5e
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Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy

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