The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development

Small ubiquitin-like modifier (SUMO) is a highly conserved post-translational modification protein, mainly found in eukaryotes. They are widely expressed in different tissues, including the liver. As an essential post-translational modification, SUMOylation is involved in many necessary regulations...

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Autores principales:	Hongchao Yuan, Yuanjun Lu, Yau-Tuen Chan, Cheng Zhang, Ning Wang, Yibin Feng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma (HCC) post-translational modification SUMOylation cancer metastasis cancer drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6b46eb3ef2854148a2d30514748ac8c6
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spelling	oai:doaj.org-article:6b46eb3ef2854148a2d30514748ac8c62021-11-25T17:02:48ZThe Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development10.3390/cancers132257002072-6694https://doaj.org/article/6b46eb3ef2854148a2d30514748ac8c62021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5700https://doaj.org/toc/2072-6694Small ubiquitin-like modifier (SUMO) is a highly conserved post-translational modification protein, mainly found in eukaryotes. They are widely expressed in different tissues, including the liver. As an essential post-translational modification, SUMOylation is involved in many necessary regulations in cells. It plays a vital role in DNA repair, transcription regulation, protein stability and cell cycle progression. Increasing shreds of evidence show that SUMOylation is closely related to Hepatocellular carcinoma (HCC). The high expression of SUMOs in the inflammatory hepatic tissue may lead to the carcinogenesis of HCC. At the same time, SUMOs will upregulate the proliferation and survival of HCC, migration, invasion and metastasis of HCC, tumour microenvironment as well as drug resistance. This study reviewed the role of SUMOylation in liver cancer. In addition, it also discussed natural compounds that modulate SUMO and target SUMO drugs in clinical trials. Considering the critical role of SUMO protein in the occurrence of HCC, the drug regulation of SUMOylation may become a potential target for treatment, prognostic monitoring and adjuvant chemotherapy of HCC.Hongchao YuanYuanjun LuYau-Tuen ChanCheng ZhangNing WangYibin FengMDPI AGarticlehepatocellular carcinoma (HCC)post-translational modificationSUMOylationcancer metastasiscancer drug resistanceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5700, p 5700 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma (HCC) post-translational modification SUMOylation cancer metastasis cancer drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma (HCC) post-translational modification SUMOylation cancer metastasis cancer drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hongchao Yuan Yuanjun Lu Yau-Tuen Chan Cheng Zhang Ning Wang Yibin Feng The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
description	Small ubiquitin-like modifier (SUMO) is a highly conserved post-translational modification protein, mainly found in eukaryotes. They are widely expressed in different tissues, including the liver. As an essential post-translational modification, SUMOylation is involved in many necessary regulations in cells. It plays a vital role in DNA repair, transcription regulation, protein stability and cell cycle progression. Increasing shreds of evidence show that SUMOylation is closely related to Hepatocellular carcinoma (HCC). The high expression of SUMOs in the inflammatory hepatic tissue may lead to the carcinogenesis of HCC. At the same time, SUMOs will upregulate the proliferation and survival of HCC, migration, invasion and metastasis of HCC, tumour microenvironment as well as drug resistance. This study reviewed the role of SUMOylation in liver cancer. In addition, it also discussed natural compounds that modulate SUMO and target SUMO drugs in clinical trials. Considering the critical role of SUMO protein in the occurrence of HCC, the drug regulation of SUMOylation may become a potential target for treatment, prognostic monitoring and adjuvant chemotherapy of HCC.
format	article
author	Hongchao Yuan Yuanjun Lu Yau-Tuen Chan Cheng Zhang Ning Wang Yibin Feng
author_facet	Hongchao Yuan Yuanjun Lu Yau-Tuen Chan Cheng Zhang Ning Wang Yibin Feng
author_sort	Hongchao Yuan
title	The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
title_short	The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
title_full	The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
title_fullStr	The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
title_full_unstemmed	The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
title_sort	role of protein sumoylation in human hepatocellular carcinoma: a potential target of new drug discovery and development
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6b46eb3ef2854148a2d30514748ac8c6
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The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development

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