COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE

Abstract. Multiple parameters of immune system were studied in patients with various clinical forms of tickborne encephalitis (TBE). The patients were examined in acute phase of the infection. It is shown that early immunopathogenesis of TBE, in its feverish form, corresponds to general immunologica...

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Autores principales:	N. V. Krylova, G. N. Leonova, E. V. Pavlenko, T. S. Zaporozhets, T. P. Smolina, A. K. Gazha, D. V. Novikov, I. V. Chenzova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tick-borne encephalitis immunopathogenesis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6b4a9ef56d36436db9432a38c2f299da
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spelling	oai:doaj.org-article:6b4a9ef56d36436db9432a38c2f299da2021-11-18T08:03:41ZCOMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE1563-06252313-741X10.15789/1563-0625-2012-4-5-313-320https://doaj.org/article/6b4a9ef56d36436db9432a38c2f299da2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/458https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Multiple parameters of immune system were studied in patients with various clinical forms of tickborne encephalitis (TBE). The patients were examined in acute phase of the infection. It is shown that early immunopathogenesis of TBE, in its feverish form, corresponds to general immunological mechanisms of viral infection. Meanwhile, in focal clinical forms of TBE with favorable outcome, we revealed a deficiency of T-cell immunity, disimmunoglobulinemia, and low Th1-cytokine production. In a focal form with fatal outcome, an early hyperproduction of Th1-cytokines and complement components, as well as increased numbers of activated T-lymphocytes have been noted, along with reduced levels of cytotoxic lymphocytes. The changes observed may be considered as early prognostic criteria of a severe infection.N. V. KrylovaG. N. LeonovaE. V. PavlenkoT. S. ZaporozhetsT. P. SmolinaA. K. GazhaD. V. NovikovI. V. ChenzovaSPb RAACIarticletick-borne encephalitisimmunopathogenesisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 313-320 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tick-borne encephalitis immunopathogenesis Immunologic diseases. Allergy RC581-607
spellingShingle	tick-borne encephalitis immunopathogenesis Immunologic diseases. Allergy RC581-607 N. V. Krylova G. N. Leonova E. V. Pavlenko T. S. Zaporozhets T. P. Smolina A. K. Gazha D. V. Novikov I. V. Chenzova COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
description	Abstract. Multiple parameters of immune system were studied in patients with various clinical forms of tickborne encephalitis (TBE). The patients were examined in acute phase of the infection. It is shown that early immunopathogenesis of TBE, in its feverish form, corresponds to general immunological mechanisms of viral infection. Meanwhile, in focal clinical forms of TBE with favorable outcome, we revealed a deficiency of T-cell immunity, disimmunoglobulinemia, and low Th1-cytokine production. In a focal form with fatal outcome, an early hyperproduction of Th1-cytokines and complement components, as well as increased numbers of activated T-lymphocytes have been noted, along with reduced levels of cytotoxic lymphocytes. The changes observed may be considered as early prognostic criteria of a severe infection.
format	article
author	N. V. Krylova G. N. Leonova E. V. Pavlenko T. S. Zaporozhets T. P. Smolina A. K. Gazha D. V. Novikov I. V. Chenzova
author_facet	N. V. Krylova G. N. Leonova E. V. Pavlenko T. S. Zaporozhets T. P. Smolina A. K. Gazha D. V. Novikov I. V. Chenzova
author_sort	N. V. Krylova
title	COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
title_short	COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
title_full	COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
title_fullStr	COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
title_full_unstemmed	COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
title_sort	comprehensive assessment of immune system in various forms of tick-borne encephalitis in acute phase
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/6b4a9ef56d36436db9432a38c2f299da
work_keys_str_mv	AT nvkrylova comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT gnleonova comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT evpavlenko comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT tszaporozhets comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT tpsmolina comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT akgazha comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT dvnovikov comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase AT ivchenzova comprehensiveassessmentofimmunesysteminvariousformsoftickborneencephalitisinacutephase
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COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE

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