CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. Here the authors show that chloride intracellular channels (CLIC) interface between mitochondria stress and inflammasome activation to modulate in...

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Autores principales:	Tiantian Tang, Xueting Lang, Congfei Xu, Xiaqiong Wang, Tao Gong, Yanqing Yang, Jun Cui, Li Bai, Jun Wang, Wei Jiang, Rongbin Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b4c27b06f164da49a36e602ca15594e
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spelling	oai:doaj.org-article:6b4c27b06f164da49a36e602ca15594e2021-12-02T14:16:04ZCLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation10.1038/s41467-017-00227-x2041-1723https://doaj.org/article/6b4c27b06f164da49a36e602ca15594e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00227-xhttps://doaj.org/toc/2041-1723The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. Here the authors show that chloride intracellular channels (CLIC) interface between mitochondria stress and inflammasome activation to modulate inflammatory responses.Tiantian TangXueting LangCongfei XuXiaqiong WangTao GongYanqing YangJun CuiLi BaiJun WangWei JiangRongbin ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tiantian Tang Xueting Lang Congfei Xu Xiaqiong Wang Tao Gong Yanqing Yang Jun Cui Li Bai Jun Wang Wei Jiang Rongbin Zhou CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
description	The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. Here the authors show that chloride intracellular channels (CLIC) interface between mitochondria stress and inflammasome activation to modulate inflammatory responses.
format	article
author	Tiantian Tang Xueting Lang Congfei Xu Xiaqiong Wang Tao Gong Yanqing Yang Jun Cui Li Bai Jun Wang Wei Jiang Rongbin Zhou
author_facet	Tiantian Tang Xueting Lang Congfei Xu Xiaqiong Wang Tao Gong Yanqing Yang Jun Cui Li Bai Jun Wang Wei Jiang Rongbin Zhou
author_sort	Tiantian Tang
title	CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
title_short	CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
title_full	CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
title_fullStr	CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
title_full_unstemmed	CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
title_sort	clics-dependent chloride efflux is an essential and proximal upstream event for nlrp3 inflammasome activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6b4c27b06f164da49a36e602ca15594e
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CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

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