CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. Here the authors show that chloride intracellular channels (CLIC) interface between mitochondria stress and inflammasome activation to modulate in...

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Autores principales: Tiantian Tang, Xueting Lang, Congfei Xu, Xiaqiong Wang, Tao Gong, Yanqing Yang, Jun Cui, Li Bai, Jun Wang, Wei Jiang, Rongbin Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/6b4c27b06f164da49a36e602ca15594e
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