Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein

Reactivation of human cytomegalovirus in immunosuppressed transplant patients can cause severe complications. Here, Krishnaet al. show that a fusion toxin protein that specifically binds the viral surface protein US28 can be used to kill latently infected monocytes and their progenitor cells in vitr...

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Autores principales:	B. A. Krishna, K. Spiess, E. L. Poole, B. Lau, S. Voigt, T. N. Kledal, M. M. Rosenkilde, J. H. Sinclair
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b51dc5db95748729925ab3ac515e35e
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spelling	oai:doaj.org-article:6b51dc5db95748729925ab3ac515e35e2021-12-02T17:01:23ZTargeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein10.1038/ncomms143212041-1723https://doaj.org/article/6b51dc5db95748729925ab3ac515e35e2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14321https://doaj.org/toc/2041-1723Reactivation of human cytomegalovirus in immunosuppressed transplant patients can cause severe complications. Here, Krishnaet al. show that a fusion toxin protein that specifically binds the viral surface protein US28 can be used to kill latently infected monocytes and their progenitor cells in vitro.B. A. KrishnaK. SpiessE. L. PooleB. LauS. VoigtT. N. KledalM. M. RosenkildeJ. H. SinclairNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q B. A. Krishna K. Spiess E. L. Poole B. Lau S. Voigt T. N. Kledal M. M. Rosenkilde J. H. Sinclair Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
description	Reactivation of human cytomegalovirus in immunosuppressed transplant patients can cause severe complications. Here, Krishnaet al. show that a fusion toxin protein that specifically binds the viral surface protein US28 can be used to kill latently infected monocytes and their progenitor cells in vitro.
format	article
author	B. A. Krishna K. Spiess E. L. Poole B. Lau S. Voigt T. N. Kledal M. M. Rosenkilde J. H. Sinclair
author_facet	B. A. Krishna K. Spiess E. L. Poole B. Lau S. Voigt T. N. Kledal M. M. Rosenkilde J. H. Sinclair
author_sort	B. A. Krishna
title	Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
title_short	Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
title_full	Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
title_fullStr	Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
title_full_unstemmed	Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
title_sort	targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6b51dc5db95748729925ab3ac515e35e
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Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein

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