A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

Abstract Dietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of...

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Autores principales:	Mariem Hajji-Louati, Emilie Cordina-Duverger, Nasser Laouali, Francesca-Romana Mancini, Pascal Guénel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b528db80c7d4647b088c77556cc48ff
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spelling	oai:doaj.org-article:6b528db80c7d4647b088c77556cc48ff2021-12-02T15:09:06ZA case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer10.1038/s41598-021-95955-y2045-2322https://doaj.org/article/6b528db80c7d4647b088c77556cc48ff2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95955-yhttps://doaj.org/toc/2045-2322Abstract Dietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.Mariem Hajji-LouatiEmilie Cordina-DuvergerNasser LaoualiFrancesca-Romana ManciniPascal GuénelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariem Hajji-Louati Emilie Cordina-Duverger Nasser Laouali Francesca-Romana Mancini Pascal Guénel A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
description	Abstract Dietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.
format	article
author	Mariem Hajji-Louati Emilie Cordina-Duverger Nasser Laouali Francesca-Romana Mancini Pascal Guénel
author_facet	Mariem Hajji-Louati Emilie Cordina-Duverger Nasser Laouali Francesca-Romana Mancini Pascal Guénel
author_sort	Mariem Hajji-Louati
title	A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
title_short	A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
title_full	A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
title_fullStr	A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
title_full_unstemmed	A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
title_sort	case–control study in france showing that a pro-inflammatory diet is associated with a higher risk of breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b528db80c7d4647b088c77556cc48ff
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A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

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