Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administrati...

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Autores principales:	Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6b54770221c34086b376c539aef6277a
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spelling	oai:doaj.org-article:6b54770221c34086b376c539aef6277a2021-12-02T14:41:13ZChronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF10.1038/s41467-020-14478-82041-1723https://doaj.org/article/6b54770221c34086b376c539aef6277a2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14478-8https://doaj.org/toc/2041-1723Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administration of Stem Cell Growth Factor SCGFa.Pradeep RamalingamMichael G. PoulosElisa LazzariMichael C. GutkinDavid LopezChristopher C. KlossMichael J. CrowleyLizabeth KatsnelsonAna G. FreireMatthew B. GreenblattChristopher Y. ParkJason M. ButlerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pradeep Ramalingam Michael G. Poulos Elisa Lazzari Michael C. Gutkin David Lopez Christopher C. Kloss Michael J. Crowley Lizabeth Katsnelson Ana G. Freire Matthew B. Greenblatt Christopher Y. Park Jason M. Butler Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
description	Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administration of Stem Cell Growth Factor SCGFa.
format	article
author	Pradeep Ramalingam Michael G. Poulos Elisa Lazzari Michael C. Gutkin David Lopez Christopher C. Kloss Michael J. Crowley Lizabeth Katsnelson Ana G. Freire Matthew B. Greenblatt Christopher Y. Park Jason M. Butler
author_facet	Pradeep Ramalingam Michael G. Poulos Elisa Lazzari Michael C. Gutkin David Lopez Christopher C. Kloss Michael J. Crowley Lizabeth Katsnelson Ana G. Freire Matthew B. Greenblatt Christopher Y. Park Jason M. Butler
author_sort	Pradeep Ramalingam
title	Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
title_short	Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
title_full	Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
title_fullStr	Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
title_full_unstemmed	Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
title_sort	chronic activation of endothelial mapk disrupts hematopoiesis via nfkb dependent inflammatory stress reversible by scgf
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6b54770221c34086b376c539aef6277a
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Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

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