Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administrati...

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Autores principales: Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/6b54770221c34086b376c539aef6277a
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