Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment

Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment

Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a precli...

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Auteurs principaux: Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig, Lukas Flatz
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/6b57b0ebdd6c41a2b423f124d18a7987
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Résumé:Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a preclinical model of melanoma.

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