Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a precli...
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Nature Portfolio
2021
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oai:doaj.org-article:6b57b0ebdd6c41a2b423f124d18a79872021-12-02T16:34:05ZViral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment10.1038/s41467-021-25057-w2041-1723https://doaj.org/article/6b57b0ebdd6c41a2b423f124d18a79872021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25057-whttps://doaj.org/toc/2041-1723Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a preclinical model of melanoma.Sandra S. RingJovana CupovicLucas OnderMechthild LütgeChristian Perez-ShibayamaCristina Gil-CruzElke ScandellaAngelina De MartinUrs MörbeFabienne HartmannRobert WengerMatthias SpieglAndrej BesseWeldy V. BonillaFelix StemesederSarah SchmidtKlaus K. OrlingerPhilippe KrebsBurkhard LudewigLukas FlatzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sandra S. Ring Jovana Cupovic Lucas Onder Mechthild Lütge Christian Perez-Shibayama Cristina Gil-Cruz Elke Scandella Angelina De Martin Urs Mörbe Fabienne Hartmann Robert Wenger Matthias Spiegl Andrej Besse Weldy V. Bonilla Felix Stemeseder Sarah Schmidt Klaus K. Orlinger Philippe Krebs Burkhard Ludewig Lukas Flatz Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| description |
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a preclinical model of melanoma. |
| format |
article |
| author |
Sandra S. Ring Jovana Cupovic Lucas Onder Mechthild Lütge Christian Perez-Shibayama Cristina Gil-Cruz Elke Scandella Angelina De Martin Urs Mörbe Fabienne Hartmann Robert Wenger Matthias Spiegl Andrej Besse Weldy V. Bonilla Felix Stemeseder Sarah Schmidt Klaus K. Orlinger Philippe Krebs Burkhard Ludewig Lukas Flatz |
| author_facet |
Sandra S. Ring Jovana Cupovic Lucas Onder Mechthild Lütge Christian Perez-Shibayama Cristina Gil-Cruz Elke Scandella Angelina De Martin Urs Mörbe Fabienne Hartmann Robert Wenger Matthias Spiegl Andrej Besse Weldy V. Bonilla Felix Stemeseder Sarah Schmidt Klaus K. Orlinger Philippe Krebs Burkhard Ludewig Lukas Flatz |
| author_sort |
Sandra S. Ring |
| title |
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| title_short |
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| title_full |
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| title_fullStr |
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| title_full_unstemmed |
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| title_sort |
viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6b57b0ebdd6c41a2b423f124d18a7987 |
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