A minimal fragment of MUC1 mediates growth of cancer cells.

The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells. However, a mechanistic link between aberrant expression and cancer has remained elusive. Herein, we report that a mem...

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Autores principales:	Sanjeev Mahanta, Shawn P Fessler, Jaehong Park, Cynthia Bamdad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6b598745533848638598ca09c5bdce3e
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spelling	oai:doaj.org-article:6b598745533848638598ca09c5bdce3e2021-11-25T06:12:37ZA minimal fragment of MUC1 mediates growth of cancer cells.1932-620310.1371/journal.pone.0002054https://doaj.org/article/6b598745533848638598ca09c5bdce3e2008-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18446242/?tool=EBIhttps://doaj.org/toc/1932-6203The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells. However, a mechanistic link between aberrant expression and cancer has remained elusive. Herein, we report that a membrane-bound MUC1 cleavage product, that we call MUC1, is the predominant form of the protein on cultured cancer cells and on cancerous tissues. Further, we demonstrate that transfection of a minimal fragment of MUC1, MUC1(1110), containing a mere forty-five (45) amino acids of the extracellular domain, is sufficient to confer the oncogenic activities that were previously attributed to the full-length protein. By comparison of molecular weight and function, it appears that MUC1* and MUC1(1110) are approximately equivalent. Evidence is presented that strongly supports a mechanism whereby dimerization of the extracellular domain of MUC1 activates the MAP kinase signaling cascade and stimulates cell growth. These findings suggest methods to manipulate this growth mechanism for therapeutic interventions in cancer treatments.Sanjeev MahantaShawn P FesslerJaehong ParkCynthia BamdadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 4, p e2054 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanjeev Mahanta Shawn P Fessler Jaehong Park Cynthia Bamdad A minimal fragment of MUC1 mediates growth of cancer cells.
description	The MUC1 protein is aberrantly expressed on many solid tumor cancers. In contrast to its apical clustering on healthy epithelial cells, it is uniformly distributed over cancer cells. However, a mechanistic link between aberrant expression and cancer has remained elusive. Herein, we report that a membrane-bound MUC1 cleavage product, that we call MUC1, is the predominant form of the protein on cultured cancer cells and on cancerous tissues. Further, we demonstrate that transfection of a minimal fragment of MUC1, MUC1(1110), containing a mere forty-five (45) amino acids of the extracellular domain, is sufficient to confer the oncogenic activities that were previously attributed to the full-length protein. By comparison of molecular weight and function, it appears that MUC1* and MUC1(1110) are approximately equivalent. Evidence is presented that strongly supports a mechanism whereby dimerization of the extracellular domain of MUC1 activates the MAP kinase signaling cascade and stimulates cell growth. These findings suggest methods to manipulate this growth mechanism for therapeutic interventions in cancer treatments.
format	article
author	Sanjeev Mahanta Shawn P Fessler Jaehong Park Cynthia Bamdad
author_facet	Sanjeev Mahanta Shawn P Fessler Jaehong Park Cynthia Bamdad
author_sort	Sanjeev Mahanta
title	A minimal fragment of MUC1 mediates growth of cancer cells.
title_short	A minimal fragment of MUC1 mediates growth of cancer cells.
title_full	A minimal fragment of MUC1 mediates growth of cancer cells.
title_fullStr	A minimal fragment of MUC1 mediates growth of cancer cells.
title_full_unstemmed	A minimal fragment of MUC1 mediates growth of cancer cells.
title_sort	minimal fragment of muc1 mediates growth of cancer cells.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/6b598745533848638598ca09c5bdce3e
work_keys_str_mv	AT sanjeevmahanta aminimalfragmentofmuc1mediatesgrowthofcancercells AT shawnpfessler aminimalfragmentofmuc1mediatesgrowthofcancercells AT jaehongpark aminimalfragmentofmuc1mediatesgrowthofcancercells AT cynthiabamdad aminimalfragmentofmuc1mediatesgrowthofcancercells AT sanjeevmahanta minimalfragmentofmuc1mediatesgrowthofcancercells AT shawnpfessler minimalfragmentofmuc1mediatesgrowthofcancercells AT jaehongpark minimalfragmentofmuc1mediatesgrowthofcancercells AT cynthiabamdad minimalfragmentofmuc1mediatesgrowthofcancercells
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A minimal fragment of MUC1 mediates growth of cancer cells.

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